Metanixin

Base Information

Chemical Name:Metanixin
CAS No.:4394-04-1
Molecular Formula:C14H14N2O2
Molecular Weight:242.2732
Hs Code.:2933399090
UNII:OWY6DMB1YX
DSSTox Substance ID:DTXSID3045693
Nikkaji Number:J9.624E
Wikidata:Q27285895
NCI Thesaurus Code:C66106
Metabolomics Workbench ID:144328
ChEMBL ID:CHEMBL2104706
Mol file:4394-04-1.mol

Synonyms:Metanixin;4394-04-1;Metanixin [INN];Acide nixylique;Acido nixilico;Acidum nixylicum;Metanixine [French];Metanixinum [Latin];Metanixino [Spanish];2-(2,6-Xylidino)nicotinic acid;OWY6DMB1YX;Metanixine [INN-French];Metanixinum [INN-Latin];Metanixino [INN-Spanish];2-[(2,6-dimethylphenyl)amino]pyridine-3-carboxylic Acid;2-(2,6-Xylidino)nicotinsaeure;DTXSID3045693;2-(2,6-dimethylanilino)pyridine-3-carboxylic acid;Nicotinic acid, 2-(2,6-xylidino)-;BRN 0482454;NICOTINIC ACID, 2-(2,3-XYLIDINO)-;3-Pyridinecarboxylic acid, 2-((2,6-dimethylphenyl)amino)-;Metanixine;Metanixino;Metanixinum;UNII-OWY6DMB1YX;SCHEMBL2107737;CHEMBL2104706;DTXCID1025693;Tox21_110969;AKOS009173650;LS-96642;CAS-4394-04-1;EN300-322397;Q27285895

Suppliers and Price of Metanixin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-[(2,6-DIMETHYLPHENYL)AMINO]PYRIDINE-3-CARBOXYLIC ACID 95.00%
5MG
$ 496.82

Total 1 raw suppliers

Chemical Property of Metanixin

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:394°Cat760mmHg
Flash Point:192.1°C
PSA：62.22000
Density:1.25g/cm³
LogP:3.21320
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:242.105527694
Heavy Atom Count:18
Complexity:286

Purity/Quality:

95% ^*data from raw suppliers

2-[(2,6-DIMETHYLPHENYL)AMINO]PYRIDINE-3-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)C)NC2=C(C=CC=N2)C(=O)O

Technology Process of Metanixin

There total 2 articles about Metanixin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 2942-59-8
2-chloronicotinic acid

: 87-62-7
2,6-dimethylaniline

: 4394-04-1
2-[(2,6-dimethylphenyl)amino]pyridine-3-carboxylic acid

Guidance literature:: With potassium carbonate; In water; at 180 ℃; for 4h; Green chemistry;
DOI:10.1007/s11164-012-0494-0

Reference yield:

: 4394-04-1
2-[(2,6-dimethylphenyl)amino]pyridine-3-carboxylic acid

Guidance literature:: 2-Chlor-nicotinsaeure, 2,6-Xylidin;

Reference yield:

: 4394-04-1
2-[(2,6-dimethylphenyl)amino]pyridine-3-carboxylic acid

: 89109-28-4
3-Butyl-1-(2,6-dimethyl-phenyl)-4-hydroxy-1H-[1,8]naphthyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetone / 1.) 0 deg C, 2.) heating, 18 h

2: 51 percent / triethylamine / methanol / 6 h / Heating

3: 63 percent / potassium tert-butoxide / 1.) 0.25 h, 2.) heating, 4 h

With potassium tert-butylate; triethylamine; In methanol; acetone;
DOI:10.1021/jm00119a010