CCT 244747

Base Information

Chemical Name:CCT 244747
CAS No.:1404095-34-6
Molecular Formula:C20H24N8O2
Molecular Weight:408.46
Hs Code.:
Mol file:1404095-34-6.mol

Synonyms:CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile

Suppliers and Price of CCT 244747

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
CCT244747 >98%
5 mg
$ 200.00

DC Chemicals
CCT244747 >98%
10 mg
$ 320.00

ChemScene
CCT244747 >99.0%
50mg
$ 900.00

ChemScene
CCT244747 >99.0%
25mg
$ 540.00

ChemScene
CCT244747 >99.0%
10mg
$ 288.00

ChemScene
CCT244747 >99.0%
2mg
$ 108.00

ChemScene
CCT244747 >99.0%
5mg
$ 180.00

Cayman Chemical
CCT244747 ≥98%
5mg
$ 168.00

Cayman Chemical
CCT244747 ≥98%
1mg
$ 56.00

Cayman Chemical
CCT244747 ≥98%
10mg
$ 280.00

Total 8 raw suppliers

Chemical Property of CCT 244747

Chemical Property:

PSA：114.01000
LogP:2.29788
Solubility.:Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

CCT244747 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G2/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G2 checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.

Technology Process of CCT 244747

There total 5 articles about CCT 244747 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1184843-17-1
(R)-5-amino-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile

: 1404095-47-1
2-chloro-4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridine

: 1404095-34-6
(R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 17h; Inert atmosphere;
DOI:10.1021/jm3012933

Reference yield:

: 17228-69-2
2-chloro-4-methoxy-pyridine

: 1404095-34-6
(R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / sulfuric acid / 2 h / 20 - 55 °C / Inert atmosphere

2: palladium(II) acetate and triphenylphosphine microencapsulated in polyurea matrix / acetonitrile; ethanol / 3 h / 105 °C / Inert atmosphere

3: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 17 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-iodo-succinimide; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; sulfuric acid; acetonitrile; 2: |Suzuki Coupling / 3: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm3012933

Reference yield:

: 1226878-98-3
2-chloro-5-iodo-4-methoxypyridine

: 1404095-34-6
(R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: palladium(II) acetate and triphenylphosphine microencapsulated in polyurea matrix / acetonitrile; ethanol / 3 h / 105 °C / Inert atmosphere

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 17 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; acetonitrile; 1: |Suzuki Coupling / 2: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm3012933