17228-69-2

Basic information

• Product Name: 2-Chloro-4-methoxypyridine
• Synonyms: IFLAB-BB F1957-0003;2-CHLORO-4-METHOXYPYRIDINE;Pyridine,2-chloro-4-Methoxy-;2-chloro-Methoxypyridine;2-Chloro-4-Methoxypyridine 97%;2-Chloro-4-methoxypyridine(RS20006968)
• CAS NO: 17228-69-2
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: -0
• Product Categories: blocks;Pyridines;Pyridine;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series
• Mol File: 17228-69-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 224-225 °C(lit.)
• Flash Point: >230 °F
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.258 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.236mmHg at 25°C
• Refractive Index: n20/D 1.5400(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Soluble in alcohol.
• PKA: 2.25±0.10(Predicted)
• BRN: 1423379
• CAS DataBase Reference: 2-Chloro-4-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-methoxypyridine(17228-69-2)
• EPA Substance Registry System: 2-Chloro-4-methoxypyridine(17228-69-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37
• RIDADR: 2810
• WGK Germany: 3
• PackingGroup: III
• Hazardous Substances Data: 17228-69-2(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

Different sources of media describe the Uses of 17228-69-2 differently. You can refer to the following data:
1. It is an active pharmaceutical ingredient.
2. 2-Chloro-4-methoxypyridine may be used to synthesize:2-(2′,4′-difluorophenyl)-4-methoxypyridine(2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl)pyrimidin-4-yl]methanol(2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl) pyrimidin-4-yl]methyl acetate

General Description

2-Chloro-4-methoxypyridine can be obtained from the reaction between 2-chloro-4-nitropyridine and sodium methoxide in the presence of dioxane. It can also be prepared starting from 4-methoxy-2(1H)-pyridone and 4-nitropyridine N-oxide.

InChI:InChI=1/C6H6ClNO/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 23056-36-2 2-chloro-4-nitropyridine 
• 52545-13-8 4-methoxypyridin-2(1H)-one 
• 38608-87-6 2-chloro-4-methoxypyridine N-oxide 
• 17368-12-6 2-chloropyridin-4-ol 
• 74-88-4 methyl iodide 
• 1124-33-0 4-nitraminopyridine N-oxide 
• 1122-96-9 4-methoxypyridine N-oxide 
• 34851-41-7 tetrabutyl ammonium methoxide 
• 124-41-4 sodium methylate 
• 26452-80-2 2,4-dichloropyridine 

Downstream Products

• 193074-46-3 2-chloro-6-cyano-4-methoxy pyridine 
• 289469-81-4 2-(4-methoxypyridin-2-yl)toluene 
• 53698-56-9 2-phenyl-4-(methoxy)pyridine 
• 387827-66-9 C₁₃H₁₀F₃NO 
• 864229-51-6 ethyl 2-chloro-4-methoxypyridine-3-carboxylate 
• 52606-07-2 5-bromo-2,4-dimethoxypyridine 
• 4904-21-6 4-cyclopropyl pyridine 
• 1448164-29-1 4-methoxy-2-(4-methoxyphenyl)pyridine 
• 1256823-05-8 6-chloro-4-methoxypyridine-3-carbaldehyde 
• 1196146-82-3 5-bromo-2-chloro-pyridin-4-ol 
• 17368-12-6 2-chloropyridin-4-ol 

Relevant articles and documents

Bright blue phosphorescence from cationic bis-cyclometalated iridium(III) isocyanide complexes

We report new bis-cyclometalated cationic iridium(III) complexes [(CN) 2Ir(CN-tert-Bu)2](CF3SO3) that have tert-butyl isocyanides as neutral auxiliary ligands and 2-phenylpyridine or 2-(4'- fluorophenyl)-R-pyridines (where R is 4-methoxy, 4-tert-butyl, or 5-trifluoromethyl) as CN ligands. The complexes are white or pale yellow solids that show irreversible reduction and oxidation processes and have a large electrochemical gap of 3.58-3.83 V. They emit blue or bluegreen phosphorescence in liquid/solid solutions from a cyclometalatingligand- centered excited state. Their emission spectra show vibronic structure with the highest-energy luminescence peak at 440-459 nm. The corresponding quantum yields and observed excitedstate lifetimes are up to 76% and 46 μs, respectively, and the calculated radiative lifetimes are in the range of 46-82 μs. In solution, the photophysical properties of the complexes are solvent-independent, and their emission color is tuned by variation of the substituents in the cyclometalating ligand. For most of the complexes, an emission color red shift occurs in going from solution to neat solids. However, the shift is minimal for the complexes with bulky tert-butyl or trifluoromethyl groups on the cyclometalating ligands that prevent aggregation. We report the first example of an iridium(III) isocyanide complex that emits blue phosphorescence not only in solution but also as a neat solid.

PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

COMPOUNDS AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.