(4-BROMO-PHENYL)-OXO-ACETALDEHYDE OXIME

Base Information

• Chemical Name: (4-BROMO-PHENYL)-OXO-ACETALDEHYDE OXIME
• CAS No.: 49615-87-4
• Molecular Formula: C8H6BrNO2
• Molecular Weight: 228.045
• Mol file: 49615-87-4.mol

Synonyms:(4-BROMO-PHENYL)-OXO-ACETALDEHYDE OXIME

Chemical Property of (4-BROMO-PHENYL)-OXO-ACETALDEHYDE OXIME

Chemical Property:

• Melting Point: 148 °C
• Boiling Point: 373.0±44.0 °C(Predicted)
• PKA: 8.14±0.10(Predicted)
• PSA: 49.66000
• Density: 1.57±0.1 g/cm3(Predicted)
• LogP: 2.09180

Purity/Quality:

(4-Bromo-phenyl)-oxo-acetaldehydeoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-BROMO-PHENYL)-OXO-ACETALDEHYDE OXIME

There total 4 articles about (4-BROMO-PHENYL)-OXO-ACETALDEHYDE OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-azido-1-(4-bromophenyl)ethanone (71559-14-3) → 2-(4-bromophenyl)-2-oxoacetaldehyde oxime (49615-87-4)

Guidance literature:

With hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dimethyl sulfoxide; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c8cc09415b

Reference yield:

methyl 3-(4-bromophenyl)-3-oxopropanoate (126629-81-0) → 2-(4-bromophenyl)-2-oxoacetaldehyde oxime (49615-87-4)

Guidance literature:

methyl 3-(4-bromophenyl)-3-oxopropanoate; With sodium hydroxide; In water; for 12h;

With perchloric acid; sodium nitrite; In water; at 20 ℃; for 14h;

DOI:10.1007/s11172-005-0359-4

Reference yield:

para-bromoacetophenone (99-90-1) + isopentyl nitrite (110-46-3) → 2-(4-bromophenyl)-2-oxoacetaldehyde oxime (49615-87-4)

Guidance literature:

With sodium ethanolate; Zerlegen des ausgeschiedenen Natriumsalzes mit Eisessig;

upstream raw materials:

para-bromoacetophenone

isopentyl nitrite

methyl 3-(4-bromophenyl)-3-oxopropanoate

2-azido-1-(4-bromophenyl)ethanone

Downstream raw materials:

4-(4-bromophenyl)-1,2,5-oxadiazol-3-amine

Cu(p-BrC₆H₄COCHNO)2

Refernces

• 1、 Sheremetev. "One-pot synthesis of 3-amino-4-aryl- and 3-amino-4-hetarylfurazans". . p. 1057 - 1059. Retrieved 2007/10/03.