1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]Piperazine

Base Information

• Chemical Name: 1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]Piperazine
• CAS No.: 747413-18-9
• Molecular Formula: C17H27BN2O2
• Molecular Weight: 302.225
• Mol file: 747413-18-9.mol

Synonyms:1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]Piperazine

Chemical Property of 1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]Piperazine

Chemical Property:

• PSA: 24.94000
• LogP: 1.74050

Purity/Quality:

98%min ^*data from raw suppliers

1-Methyl-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]Piperazine

There total 4 articles about 1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]Piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ 1-methyl-4-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]piperazine (747413-18-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 4h; Schlenk technique; Inert atmosphere; Sealed tube;

Reference yield: 55.6%

1-((3-bromophenyl)sulfonyl)-4-methylpiperazine (486422-19-9) + bis(pinacol)diborane (73183-34-3) → 1-methyl-4-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]piperazine (747413-18-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; at 80 ℃; for 12h;

DOI:10.1021/jm400349k

Reference yield:

1-bromo-3-(4-methylpiperazin-1-yl)benzene (747413-17-8) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 1-methyl-4-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]piperazine (747413-18-9)

Guidance literature:

With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; toluene; at 100 ℃; for 1h; Irradiation;

upstream raw materials:

1-bromo-3-(4-methylpiperazin-1-yl)benzene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

1-((3-bromophenyl)sulfonyl)-4-methylpiperazine

bis(pinacol)diborane

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