Pyrazin-2-yl-acetic acid ethyl ester

Base Information

• Chemical Name: Pyrazin-2-yl-acetic acid ethyl ester
• CAS No.: 1060815-23-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2933990090
• Mol file: 1060815-23-7.mol

Synonyms:Pyrazin-2-yl-acetic acid ethyl ester;2-Pyrazineacetic acid, ethyl ester

Chemical Property of Pyrazin-2-yl-acetic acid ethyl ester

Chemical Property:

• PSA: 52.08000
• LogP: 0.58220

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-(Pyrazin-2-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazin-2-yl-acetic acid ethyl ester

There total 1 articles about Pyrazin-2-yl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-chloropyrazin (14508-49-7) + bromo(2-ethoxy-2-oxoethyl)zinc (5764-82-9) → ethyl 2-pyrazin-2-ylacetate (1060815-23-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N,N,N,-tetramethylethylenediamine; C₃₈H₆₂P₂; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.202016048

Reference yield: 76.0%

p-aminophenylacetonitrile (3544-25-0) + ethyl 2-pyrazin-2-ylacetate (1060815-23-7) → 4'-cyanomethyl-2-(pyrazin-2-yl)acetanilide (1160620-12-1)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 19h; Reflux;

DOI:10.1016/j.ejmech.2009.01.022

Reference yield: 64.0%

ethyl 2-pyrazin-2-ylacetate (1060815-23-7) + 1-(phenylethynyl)-3,3-bis(trifluoromethyl)-1,3-dihydro-1λ3-benzo[d][1,2]iodaoxole → ethyl 6-phenyl-7-(phenylethynyl)pyrrolo[1,2-a]pyrazine-8-carboxylate

Guidance literature:

With 1,10-Phenanthroline; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); silver(I) triflimide; In acetonitrile; at 50 ℃;

DOI:10.1021/acs.orglett.1c03667

upstream raw materials:

2-chloropyrazin

bromo(2-ethoxy-2-oxoethyl)zinc

Downstream raw materials:

4'-cyanomethyl-2-(pyrazin-2-yl)acetanilide

Refernces