3-AMino-6-fluoro-2-Methoxybenzoic Acid Methyl Ester

Base Information

• Chemical Name: 3-AMino-6-fluoro-2-Methoxybenzoic Acid Methyl Ester
• CAS No.: 1268830-91-6
• Molecular Formula: C9H10FNO3
• Molecular Weight: 199.182
• Mol file: 1268830-91-6.mol

Synonyms:3-AMino-6-fluoro-2-Methoxybenzoic Acid Methyl Ester;Methyl 3-amino-6-fluoro-2-methoxy benzoate

Chemical Property of 3-AMino-6-fluoro-2-Methoxybenzoic Acid Methyl Ester

Chemical Property:

• PSA: 61.55000
• LogP: 1.78430

Purity/Quality:

99%+ ^*data from raw suppliers

3-Amino-6-fluoro-2-methoxybenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Amino-6-fluoro-2-methoxybenzoic Acid Methyl Ester is an intermediate for the synthesis of pharmaceutical goods.

Technology Process of 3-AMino-6-fluoro-2-Methoxybenzoic Acid Methyl Ester

There total 3 articles about 3-AMino-6-fluoro-2-Methoxybenzoic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 6-fluoro-2-methoxy-3-nitrobenzoate (1268830-89-2) → methyl 3-amino-6-fluoro-2-methoxybenzoate (1268830-91-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 60h; under 760.051 Torr; Inert atmosphere;

Reference yield:

2,6-difluoro-3-nitrobenzoic acid (83141-10-0) → methyl 3-amino-6-fluoro-2-methoxybenzoate (1268830-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 2 h / Cooling with water bath

2: -4 - 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 60 h / 20 °C / 760.05 Torr / Inert atmosphere

With methanol; hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield:

methyl 2,6-difluoro-3-nitrobenzoate (84832-01-9) → methyl 3-amino-6-fluoro-2-methoxybenzoate (1268830-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: -4 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 60 h / 20 °C / 760.05 Torr / Inert atmosphere

With hydrogen; palladium 10% on activated carbon; In methanol;

upstream raw materials:

2,6-difluoro-3-nitrobenzoic acid

methyl 2,6-difluoro-3-nitrobenzoate

methyl 6-fluoro-2-methoxy-3-nitrobenzoate

Downstream raw materials:

methyl 6-fluoro-2-methoxy-3-(propylsulfonamido)benzoate

methyl 6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))benzoate

6-fluoro-2-methoxy-3-(N-(4-methoxybenzyl)(propylsulfonamido))benzoic acid

N-(3-amino-4-fluoro-2-methoxyphenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

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