Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 2'-chloro-4',5'-dihydro-

Base Information

Chemical Name:Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 2'-chloro-4',5'-dihydro-
CAS No.:1307381-31-2
Molecular Formula:C11H14ClNOS
Molecular Weight:243.757
Hs Code.:2933399990
Mol file:1307381-31-2.mol

Synonyms:Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 2'-chloro-4',5'-dihydro-

Suppliers and Price of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 2'-chloro-4',5'-dihydro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2'-Chloro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] 95+%
1g
$ 693.00

Chemenu
2''-chloro-4'',5''-dihydrospiro[piperidine-4,7''-thieno[2,3-c]pyran] 95%
1g
$ 655.00

American Custom Chemicals Corporation
2'-CHLORO-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] 95.00%
5MG
$ 499.33

Alichem
2'-Chloro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]
1g
$ 569.64

Total 21 raw suppliers

Chemical Property of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 2'-chloro-4',5'-dihydro-

Chemical Property:

PSA：49.50000
LogP:2.88170
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2'-Chloro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 2'-chloro-4',5'-dihydro-

There total 6 articles about Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 2'-chloro-4',5'-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1307248-45-8
tert-butyl 2′-chloro-4′,5′-dihydrospiro-[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

: 1307381-31-2
2'-chloro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;
DOI:10.1021/jm201629q

Reference yield:

: 1283095-48-6
tert-butyl-4′,5′-dihydro-1H-spiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

: 1307381-31-2
2'-chloro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide / acetonitrile / 70 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

With hydrogenchloride; N-chloro-succinimide; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm201629q

Reference yield:

: 13781-67-4
3-(2-hydroxyethyl)thiophene

: 1307381-31-2
2'-chloro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane; tetrahydrofuran / 25 °C

2: dmap; triethylamine / tert-butyl methyl ether / 3.5 h / -5 - 0 °C / Industrial scale

3: dmap; N-chloro-succinimide / acetonitrile / 4 h / 65 - 72 °C / Industrial scale

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone; acetic acid / water; 1,4-dioxane / 80 °C

With dmap; N-chloro-succinimide; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; dichloromethane; tert-butyl methyl ether; water; acetonitrile;
DOI:10.1021/op5000094