Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',5'-dihydro-, 1,1-diMethylethyl ester

Base Information

Chemical Name:Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',5'-dihydro-, 1,1-diMethylethyl ester
CAS No.:1307248-45-8
Molecular Formula:C₁₆H₂₂ClNO₃S
Molecular Weight:343.875
Hs Code.:
Mol file:1307248-45-8.mol

Synonyms:tert-butyl 2′-chloro-4′,5′-dihydrospiro-[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

Suppliers and Price of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',5'-dihydro-, 1,1-diMethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',5'-dihydro-, 1,1-diMethylethyl ester

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',5'-dihydro-, 1,1-diMethylethyl ester

There total 7 articles about Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',5'-dihydro-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1283095-48-6
tert-butyl-4′,5′-dihydro-1H-spiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

: 1307248-45-8
tert-butyl 2′-chloro-4′,5′-dihydrospiro-[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

Guidance literature:: With N-chloro-succinimide; In acetonitrile; at 70 ℃;
DOI:10.1021/jm201629q

Reference yield: 53.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1307248-42-5
2'-chloro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] hydrochloride

: 1307248-45-8
tert-butyl 2′-chloro-4′,5′-dihydrospiro-[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

Guidance literature:: With triethylamine; dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 13781-67-4
3-(2-hydroxyethyl)thiophene

: 1307248-45-8
tert-butyl 2′-chloro-4′,5′-dihydrospiro-[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 20 °C

1.2: 20.08 h / 14 - 30 °C

2.1: sodium hydroxide; water / dichloromethane / Cooling with ice

3.1: 2-methyltetrahydrofuran / 22 °C

4.1: acetic acid; sulfuryl dichloride / tert-butyl methyl ether / 21.17 h / 15 - 22 °C

5.1: triethylamine / dmap / dichloromethane / 20 °C

With sulfuryl dichloride; water; acetic acid; triethylamine; sodium hydroxide; dmap; In 2-methyltetrahydrofuran; dichloromethane; tert-butyl methyl ether;