Technology Process of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',5'-dihydro-, 1,1-diMethylethyl ester
There total 7 articles about Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]-1-carboxylic acid, 2'-chloro-4',5'-dihydro-, 1,1-diMethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-chloro-succinimide;
In
acetonitrile;
at 70 ℃;
DOI:10.1021/jm201629q
- Guidance literature:
-
With
triethylamine;
dmap;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dichloromethane / 20 °C
1.2: 20.08 h / 14 - 30 °C
2.1: sodium hydroxide; water / dichloromethane / Cooling with ice
3.1: 2-methyltetrahydrofuran / 22 °C
4.1: acetic acid; sulfuryl dichloride / tert-butyl methyl ether / 21.17 h / 15 - 22 °C
5.1: triethylamine / dmap / dichloromethane / 20 °C
With
sulfuryl dichloride; water; acetic acid; triethylamine; sodium hydroxide;
dmap;
In
2-methyltetrahydrofuran; dichloromethane; tert-butyl methyl ether;