[4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL

Base Information

Chemical Name:[4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL
CAS No.:1514-01-8
Molecular Formula:C₆H₆F₃N₃O
Molecular Weight:193.128
Hs Code.:
Mol file:1514-01-8.mol

Synonyms:[4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL;IFLAB-BB F2124-0861;5-PYRIMIDINEMETHANOL, 4-AMINO-2-(TRIFLUOROMETHYL)-;AKOS A0602-0735

Suppliers and Price of [4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
[4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL 95.00%
5MG
$ 502.45

Total 6 raw suppliers

Chemical Property of [4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL

Chemical Property:

PSA：72.03000
LogP:1.15110

Purity/Quality:

99% ^*data from raw suppliers

[4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL

There total 3 articles about [4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL]METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

: 653-95-2
4-amino-2-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester

: 1514-01-8
4-amino-5-(hydroxymethyl)-2-(trifluoromethyl)pyrimidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

Reference yield:

: 720-01-4
ethyl 2-trifluoromethyl-4-chloropyrimidine-5-carboxylate

: 1514-01-8
4-amino-5-(hydroxymethyl)-2-(trifluoromethyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃

2: diethyl ether; LiAlH₄

With lithium aluminium tetrahydride; diethyl ether; ammonia;
DOI:10.1021/jo01084a012

Reference yield:

: C₁₇H₁₈F₃N₃O₄

: 1514-01-8
4-amino-5-(hydroxymethyl)-2-(trifluoromethyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 12 h / 40 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;