5-Fluoro-2-hydroxyphenylboronic acid

Base Information

• Chemical Name: 5-Fluoro-2-hydroxyphenylboronic acid
• CAS No.: 259209-20-6
• Molecular Formula: C6H6BFO3
• Molecular Weight: 155.921
• Hs Code.: 2931900090
• European Community (EC) Number: 675-643-9
• DSSTox Substance ID: DTXSID80396211
• Nikkaji Number: J3.290.651F
• Wikidata: Q82196800
• Mol file: 259209-20-6.mol

Synonyms:5-Fluoro-2-hydroxyphenylboronic acid;259209-20-6;(5-fluoro-2-hydroxyphenyl)boronic acid;5-fluoro-2-hydroxybenzeneboronic acid;Boronic acid, (5-fluoro-2-hydroxyphenyl)-;MFCD03095357;(5-fluoro-2-hydroxy)phenylboronic acid;(5-fluoro-2-hydroxy-phenyl)boronic Acid;Boronic acid, B-(5-fluoro-2-hydroxyphenyl)-;SCHEMBL319589;DTXSID80396211;TWDQSJDFXUMAOI-UHFFFAOYSA-N;2-(Dihydroxyboryl)-4-fluorophenol;2-hydroxy-5-fluorophenylboronic acid;(5-fluoro-2-hydroxyphenyl)boronicacid;2-hydroxy-5-fluorophenyl-boronic acid;5-fluoro-2-hydroxy-phenylboronic acid;5-fluoro-2-hydroxyphenyl-boronic acid;AKOS000285056;CS-W020608;PS-9529;5-fluoro-2-hydroxy phenyl boronic acid;AC-16596;AM803598;SY047598;F0977;FT-0647390;EN300-6769050;5-Fluoro-2-hydroxyphenylboronic acid, AldrichCPR;J-517505;Z1201622111;5-fluoro-2-hydroxyphenylboronic acid (contains varying amounts of anhydride)

Chemical Property of 5-Fluoro-2-hydroxyphenylboronic acid

Chemical Property:

• Vapor Pressure: 0.00011mmHg at 25°C
• Melting Point: 160-166 °C
• Refractive Index: 1.552
• Boiling Point: 347.1 °C at 760mmHg
• PKA: 7.58±0.58(Predicted)
• Flash Point: 163.7 °C
• PSA: 60.69000
• Density: 1.42 g/cm³
• LogP: -0.78890
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 156.0394024
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-2-hydroxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=C(C=CC(=C1)F)O)(O)O
• Uses: suzuki reaction

Technology Process of 5-Fluoro-2-hydroxyphenylboronic acid

There total 5 articles about 5-Fluoro-2-hydroxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C8H10BFO3 → 5-fluoro-2-hydroxyphenyl-boronic acid (259209-20-6)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1039/c5dt02138c

Reference yield: 62.0%

→ 5-fluoro-2-hydroxyphenyl-boronic acid (259209-20-6)

Guidance literature:

Reference yield: 47.0%

2-(4-fluorophenoxy)tetrahydro-2H-pyran (259209-11-5) → 5-fluoro-2-hydroxyphenyl-boronic acid (259209-20-6)

Guidance literature:

upstream raw materials:

boron tribromide

(5-fluoro-2-methoxyphenyl)boronic acid

2-(4-fluorophenoxy)tetrahydro-2H-pyran

Downstream raw materials:

tert-butyl ({4-[2-(2-aminopyridin-4-yl)-4-fluorophenoxy]-5-chloro-2-fluorophenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

4-[2-(2-aminopyridin-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

C₂₈H₂₈ClF₂N₅O₆S₂