7,8-Dihydro-5H-thiopyrano[4,3-d]pyriMidine-2,4-diol

Base Information

• Chemical Name: 7,8-Dihydro-5H-thiopyrano[4,3-d]pyriMidine-2,4-diol
• CAS No.: 857956-61-7
• Molecular Formula: C₇H₈N₂O₂S
• Molecular Weight: 184.219
• Hs Code.: 2934999090
• Mol file: 857956-61-7.mol

Synonyms:7,8-Dihydro-5H-thiopyrano[4,3-d]pyriMidine-2,4-diol;7,8-dihydro-1H-thiopyrano[4,3-d]pyrimidine-2,4(3H,5H)-dione

Chemical Property of 7,8-Dihydro-5H-thiopyrano[4,3-d]pyriMidine-2,4-diol

Chemical Property:

• PSA: 91.54000
• LogP: 0.67710
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

7,8-Dihydro-5H-thiopyrano[4,3-d]pyrimidine-2,4-diol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,8-Dihydro-5H-thiopyrano[4,3-d]pyriMidine-2,4-diol

There total 6 articles about 7,8-Dihydro-5H-thiopyrano[4,3-d]pyriMidine-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.2%

3-methoxycarbonyltetrahydropyran-4-one (4160-61-6) + urea (57-13-6) → 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine-2,4-diol (857956-61-7)

Guidance literature:

With sodium methylate; at 80 ℃; for 5h;

DOI:10.1016/j.bmc.2020.115669

Reference yield: 76.2%

3-methoxycarbonyltetrahydropyran-4-one (4160-61-6) → 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine-2,4-diol (857956-61-7)

Guidance literature:

With sodium methylate; urea; at 80 ℃; for 5h;

Reference yield: 41.2%

3-methoxycarbonyltetrahydropyran-4-one (4160-61-6) + urea (57-13-6) → 7,8-dihydro-1H-thiopyrano[4,3-d]pyrimidine-2,4(3H,5H)-dione (857956-61-7)

Guidance literature:

With sodium; In ethanol; for 24h;

upstream raw materials:

3-methoxycarbonyltetrahydropyran-4-one

urea

Dimethyl 3,3'-thiodipropionate

Downstream raw materials:

2,4-dichloro-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine

PF-05139962