Technology Process of (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-alpha-L-lyxo-hexopyranoside
There total 34 articles about (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-alpha-L-lyxo-hexopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4’-epidaunorubicin; trifluoroacetic anhydride;
In
ethyl acetate;
Inert atmosphere;
With
sodium hydroxide;
In
methanol; ethyl acetate;
at 20 ℃;
for 1h;
- Guidance literature:
-
With
pyridine;
In
diethyl ether;
at -20 ℃;
for 0.166667h;
DOI:10.1021/jm00157a026
- Guidance literature:
-
daunorubicin hydrochloride; trifluoroacetic anhydride;
In
dichloromethane;
at 0 ℃;
for 1h;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
methanol; dichloromethane; water;
at 20 ℃;
pH=7 - 8;
Temperature;