N-(Trifluoroacetyl)-1-desmethyl Daunorubicin

Base Information

Chemical Name:N-(Trifluoroacetyl)-1-desmethyl Daunorubicin
CAS No.:68594-06-9
Molecular Formula:C28H26F3NO11
Molecular Weight:609.51
Hs Code.:
DSSTox Substance ID:DTXSID40570353
Wikidata:Q82457767
Mol file:68594-06-9.mol

Synonyms:N-(Trifluoroacetyl)-1-desmethyl Daunorubicin;68594-06-9;N-[(2S,3S,4S,6R)-6-[[(1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]-3-hydroxy-2-methyloxan-4-yl]-2,2,2-trifluoroacetamide;DTXSID40570353;(1S,3S)-3-Acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-alpha-L-lyxo-hexopyranoside

Suppliers and Price of N-(Trifluoroacetyl)-1-desmethyl Daunorubicin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
N-(Trifluoroacetyl)-1-desmethylDaunorubicin
2.5 mg
$ 625.00

Biosynth Carbosynth
N-(Trifluoroacetyl)-1-desmethyl daunorubicin
2 mg
$ 227.10

Biosynth Carbosynth
N-(Trifluoroacetyl)-1-desmethyl daunorubicin
1 mg
$ 124.90

Biosynth Carbosynth
N-(Trifluoroacetyl)-1-desmethyl daunorubicin
5 mg
$ 413.00

Biosynth Carbosynth
N-(Trifluoroacetyl)-1-desmethyl daunorubicin
10 mg
$ 750.80

Biosynth Carbosynth
N-(Trifluoroacetyl)-1-desmethyl daunorubicin
25 mg
$ 1365.00

AK Scientific
N-(Trifluoroacetyl)-1-desmethylDaunorubicin
10mg
$ 1063.00

AK Scientific
N-(Trifluoroacetyl)-1-desmethylDaunorubicin
2mg
$ 356.00

Total 6 raw suppliers

Chemical Property of N-(Trifluoroacetyl)-1-desmethyl Daunorubicin

Chemical Property:

PSA：203.41000
LogP:2.28600
Solubility.:Acetone
XLogP3:2.9
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:4
Exact Mass:609.14579513
Heavy Atom Count:43
Complexity:1150

Purity/Quality:

99% ^*data from raw suppliers

N-(Trifluoroacetyl)-1-desmethylDaunorubicin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)O)O)(C(=O)C)O)NC(=O)C(F)(F)F)O
Isomeric SMILES:C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)O)O)(C(=O)C)O)NC(=O)C(F)(F)F)O
Uses Daunorubicinc (D194500) derivative.

Technology Process of N-(Trifluoroacetyl)-1-desmethyl Daunorubicin

There total 4 articles about N-(Trifluoroacetyl)-1-desmethyl Daunorubicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 52794-97-5
carminomycin I hydrochloride

: 407-25-0
trifluoroacetic anhydride

: 68594-06-9
4-demethyl-3'-trifluoroacetamido-daunorubicine

Guidance literature:: With triethylamine; In chloroform; at 0 ℃; for 0.166667h;

Reference yield:

: 26388-52-3,52471-41-7,64686-33-5
3'-N-trifluoroacetyldaunorubicin

: 68594-06-9
4-demethyl-3'-trifluoroacetamido-daunorubicine

Guidance literature:: 3'-N-trifluoroacetyldaunorubicin; With magnesium chloride; In tetrahydrofuran; at 40 ℃; for 1.5h;

With water; trifluoroacetic acid; In tetrahydrofuran; pH=2.5;

Reference yield:

: 23541-50-6
daunomycin hydrochloride

: 68594-06-9
4-demethyl-3'-trifluoroacetamido-daunorubicine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 1.5 h / 0 °C

2.1: potassium iodide; magnesium chloride / tetrahydrofuran / 1.5 h / 40 °C

2.2: pH 2.5 / Cooling with ice

With potassium iodide; magnesium chloride; In tetrahydrofuran; dichloromethane;