b-AMino-2-(trifluoroMethyl)benzeneethanol

Base Information

• Chemical Name: b-AMino-2-(trifluoroMethyl)benzeneethanol
• CAS No.: 325153-01-3
• Molecular Formula: C9H10F3NO
• Molecular Weight: 205.18
• Mol file: 325153-01-3.mol

Synonyms:b-AMino-2-(trifluoroMethyl)benzeneethanol;2-AMINO-2-[2-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL

Chemical Property of b-AMino-2-(trifluoroMethyl)benzeneethanol

Chemical Property:

• Boiling Point: 287.8±35.0 °C(Predicted)
• PKA: 12.37±0.10(Predicted)
• PSA: 46.25000
• Density: 1.301±0.06 g/cm3(Predicted)
• LogP: 2.39780

Purity/Quality:

99% ^*data from raw suppliers

2-amino-2-[2-(trifluoromethyl)phenyl]ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of b-AMino-2-(trifluoroMethyl)benzeneethanol

There total 5 articles about b-AMino-2-(trifluoroMethyl)benzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(trifluoromethyl)-DL-phenylglycine (240490-00-0) → 2-amino-2-(2-(trifluoromethyl)phenyl)ethan-1-ol (325153-01-3)

Guidance literature:

2-(trifluoromethyl)-DL-phenylglycine; With borane-THF; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Cooling with ice bath;

With hydrogenchloride; water; In tetrahydrofuran;

With sodium hydrogencarbonate; sodium hydroxide; In water;

Reference yield:

2-(trifluoromethyl)phenethyl 2,2,2-trichloroacetimidate → 2-amino-2-(2-(trifluoromethyl)phenyl)ethan-1-ol (325153-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; [bis(acetoxy)iodo]benzene / acetonitrile / 2 h / Irradiation; Inert atmosphere

2: hydrogenchloride / methanol; water / 2 h

With hydrogenchloride; [bis(acetoxy)iodo]benzene; sodium iodide; In methanol; water; acetonitrile;

DOI:10.1021/jacs.7b05214

Reference yield:

C11H7Cl3F3NO → 2-amino-2-(2-(trifluoromethyl)phenyl)ethan-1-ol (325153-01-3)

Guidance literature:

With hydrogenchloride; In methanol; water; for 2h;

DOI:10.1021/jacs.7b05214

upstream raw materials:

2-(trifluoromethyl)-DL-phenylglycine

2-[2-(trifluoromethyl)phenyl]ethanol

Downstream raw materials:

2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}acetamide

tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

2-Amino-2-[2-(trifluoromethyl)phenyl]ethanol hydrochloride