tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

Base Information

• Chemical Name: tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate
• CAS No.: 1245622-61-0
• Molecular Formula: C₁₄H₁₈F₃NO₃
• Molecular Weight: 305.297
• Mol file: 1245622-61-0.mol

Synonyms:tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

Chemical Property of tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

There total 2 articles about tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-Amino-2-[2-(trifluoromethyl)phenyl]ethanol hydrochloride (1245622-60-9,1391449-79-8,1391539-49-3) → tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate (1245622-61-0)

Guidance literature:

2-Amino-2-[2-(trifluoromethyl)phenyl]ethanol hydrochloride; With sodium hydrogencarbonate; In 1,4-dioxane; water;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-2-(2-(trifluoromethyl)phenyl)ethan-1-ol (325153-01-3) → tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate (1245622-61-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2017.12.095

Reference yield: 100.0%

isocyanate de chlorosulfonyle (1189-71-5) + tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate (1245622-61-0) → 2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride (1245622-62-1)

Guidance literature:

isocyanate de chlorosulfonyle; tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate; In acetonitrile; at -15 ℃; for 0.166667h;

With water; In acetonitrile; at -15 - 60 ℃;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.0833333h;

upstream raw materials:

di-tert-butyl dicarbonate

2-Amino-2-[2-(trifluoromethyl)phenyl]ethanol hydrochloride

2-amino-2-(2-(trifluoromethyl)phenyl)ethan-1-ol

Downstream raw materials:

2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride

tert-butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

tert-butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate