SalbutaMol DiMer

Base Information

• Chemical Name: SalbutaMol DiMer
• CAS No.: 149222-15-1
• Molecular Formula: C₂₆H₄₀N₂O₅
• Molecular Weight: 460.614
• Mol file: 149222-15-1.mol

Synonyms:5-[[5-[2-[(1,1-DiMethylethyl)aMino]-1-hydroxyethyl]-2-hydroxyphenyl]Methyl]-α1-[[(1,1-diMethylethyl)aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol;SalbutaMol DiMer;SalbutaMol IMpurity N

Chemical Property of SalbutaMol DiMer

Chemical Property:

• Boiling Point: 681.1±50.0 °C(Predicted)
• PKA: 9.96±0.50(Predicted)
• PSA: 125.21000
• Density: 1.176±0.06 g/cm3(Predicted)
• LogP: 3.80570

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Albuterol Dimer is an impurity of Albuterol (Salbutamol) (A514500).

Technology Process of SalbutaMol DiMer

There total 8 articles about SalbutaMol DiMer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester (438246-25-4) → salbutamol dimer (149222-15-1)

Guidance literature:

With methanol; hydrazine; for 1h; Heating;

DOI:10.1016/S0040-4039(01)02354-1

Reference yield:

4-bromo-phenol (106-41-2) → salbutamol dimer (149222-15-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 94 percent / H₂SO₄ / 18 h / -10 - 0 °C

2: 38 percent / NaOH / 72 h / 50 °C

3: 94 percent / DMAP; pyridin / 2 h

4: 50 percent / PdCl₂(PPh₃)2 / toluene / 95 °C

5: 98 percent / NBS; aq. DMSO / 0.5 h

6: 57 percent / NaH / dimethylformamide; tetrahydrofuran / 0.5 h

7: 66 percent / isopropanol / 2 h / Heating

8: 74 percent / hydrazine; MeOH / 1 h / Heating

With pyridine; methanol; dmap; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-Bromosuccinimide; sulfuric acid; sodium hydride; dimethyl sulfoxide; isopropyl alcohol; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(01)02354-1

Reference yield:

5,5'-dibromo-2,2'-dihydroxy-diphenyl-methane (78563-03-8) → salbutamol dimer (149222-15-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 38 percent / NaOH / 72 h / 50 °C

2: 94 percent / DMAP; pyridin / 2 h

3: 50 percent / PdCl₂(PPh₃)2 / toluene / 95 °C

4: 98 percent / NBS; aq. DMSO / 0.5 h

5: 57 percent / NaH / dimethylformamide; tetrahydrofuran / 0.5 h

6: 66 percent / isopropanol / 2 h / Heating

7: 74 percent / hydrazine; MeOH / 1 h / Heating

With pyridine; methanol; dmap; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-Bromosuccinimide; sodium hydride; dimethyl sulfoxide; isopropyl alcohol; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(01)02354-1

upstream raw materials:

acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester

4-bromo-phenol

5,5'-dibromo-2,2'-dihydroxy-diphenyl-methane

4-Bromo-2-(5-bromo-2-hydroxy-benzyl)-6-hydroxymethyl-phenol

Refernces