78563-03-8

Basic information

• Product Name: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE
• Synonyms: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE
• CAS NO: 78563-03-8
• Molecular Formula: C₁₃H₁₀Br₂O₂
• Molecular Weight: 358.03
• Mol File: 78563-03-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE(78563-03-8)
• EPA Substance Registry System: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE(78563-03-8)

Safety Data

• Hazardous Substances Data: 78563-03-8(Hazardous Substances Data)

Usage

Uses

2,2''-Methylenebis(4-bromophenol) can be derived from bromophenols from the red alga Odonthalia corymbifera and display potential antimicrobial activity. It is used as an intermediate in the synthesis of Albuterol Dimer (A514515) which is an impurity of the drug Albuterol used to treat asthma.

Upstream product

• 50-00-0 formaldehyd 
• 106-41-2 4-bromo-phenol 
• 2316-64-5 5-bromo-2-hydroxybenzyl alcohol 
• 7664-93-9 sulfuric acid 
• 2467-02-9 Bis(2-hydroxyphenyl)methane 

Downstream Products

• 2212-47-7 2,2'-dimethoxy-5,5'-dibromodiphenylmethane 
• 20748-79-2 2,2'-dihydroxy-3,3'-methanediyl-di-benzyl alcohol 
• 71840-29-4 bis-(2-benzoyloxy-phenyl)-methane 
• 92-83-1 xanthene 
• 438246-20-9 4-Bromo-2-(5-bromo-2-hydroxy-benzyl)-6-hydroxymethyl-phenol 
• 2467-02-9 Bis(2-hydroxyphenyl)methane 
• 149222-15-1 salbutamol dimer 
• 438246-23-2 acetic acid 2-[2-acetoxy-5-(2-bromo-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-bromo-1-hydroxy-ethyl)-phenyl ester 
• 438246-24-3 acetic acid 2-acetoxymethyl-6-(2-acetoxy-5-oxiranyl-benzyl)-4-oxiranyl-phenyl ester 
• 438246-22-1 acetic acid 2-acetoxymethyl-6-(2-acetoxy-5-vinyl-benzyl)-4-vinyl-phenyl ester 
• 438246-21-0 acetic acid 2-(2-acetoxy-5-bromo-benzyl)-6-acetoxymethyl-4-bromo-phenyl ester 
• 83143-07-1 1-[3-(3-Acetyl-5-bromo-2-hydroxy-benzoyl)-5-bromo-2-hydroxy-phenyl]-ethanone 
• 83143-04-8 1-[3-(3-Acetyl-5-bromo-2-hydroxy-benzyl)-5-bromo-2-hydroxy-phenyl]-ethanone 
• 83143-21-9 Acetic acid 2-(2-acetoxy-5-bromo-benzoyl)-4-bromo-phenyl ester 

Relevant articles and documents

ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

Synthesis of a salbutamol dimer

First synthesis of the diastereomeric mixture of Salbutamol dimer (2) is described. The synthesis provides access to multi-gram quantities of 2 for reference supplies and further analytical and toxicology investigations. It also confirmed the proposed str

The Synthesis of Polyfunctional Aromatic Ring Systems. Structural Analogues of Phloroglucides, Aranciamycin, Cryptosporin and Terramycin

The synthesis of the title compounds is described.Some of the compounds prepared were found to be active against a number of pathogenic microorganisms in vitro.