(R,R)-2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-BIS(METHYLPHENYLPHOSPHINO)XANTHENE

Base Information

• Chemical Name: (R,R)-2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-BIS(METHYLPHENYLPHOSPHINO)XANTHENE
• CAS No.: 201226-88-2
• Molecular Formula: C₃₇H₄₄OP₂
• Molecular Weight: 566.703
• Mol file: 201226-88-2.mol

Synonyms:(R,R)-2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-BIS(METHYLPHENYLPHOSPHINO)XANTHENE;(S,S)-2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-BIS(METHYLPHENYLPHOSPHINO)XANTHENE

Chemical Property of (R,R)-2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-BIS(METHYLPHENYLPHOSPHINO)XANTHENE

Chemical Property:

• PSA: 36.41000
• LogP: 8.83820

Purity/Quality:

85.0-99.9% ^*data from raw suppliers

(R,R)-2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-BIS(METHYLPHENYLPHOSPHINO)XANTHENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,R)-2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-BIS(METHYLPHENYLPHOSPHINO)XANTHENE

There total 6 articles about (R,R)-2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-BIS(METHYLPHENYLPHOSPHINO)XANTHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,7-Di-tert-butyl-9,9-dimethyl-4,5-bis-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene → 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphanyl)-5-((S)-methyl-phenyl-phosphanyl)-9H-xanthene (201226-88-2)

Guidance literature:

With titanium(IV) isopropylate; polymethyl hydrosiloxane; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4039(97)10363-X

Reference yield:

methyl(phenyl)chlorophosphine (15849-86-2,540513-01-7) → 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphanyl)-5-((S)-methyl-phenyl-phosphanyl)-9H-xanthene (201226-88-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-butyllithium; 2.) hydrogen peroxide / 1.) THF, -78 deg C, 30 + 30 min, then room temp., 12 h; 2.) THF, H₂O, 0 deg C, then reflux, 2 h

2: 61 percent / 1.) LiAlH₄ / tetrahydrofuran / 14 h / Ambient temperature; 1.) 0 deg C

4: titanium tetraisopropoxide, polymethyl hydrosiloxane / tetrahydrofuran / Heating

With titanium(IV) isopropylate; lithium aluminium tetrahydride; n-butyllithium; polymethyl hydrosiloxane; dihydrogen peroxide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(97)10363-X

Reference yield:

2,7-Di-tert-butyl-9,9-dimethyl-4,5-bis-((R)-methyl-phenyl-phosphinoyl)-9H-xanthene (201226-91-7) → 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphanyl)-5-((S)-methyl-phenyl-phosphanyl)-9H-xanthene (201226-88-2)

Guidance literature:

With titanium(IV) isopropylate; polymethyl hydrosiloxane; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4039(97)10363-X

upstream raw materials:

2,7-Di-tert-butyl-9,9-dimethyl-4,5-bis-((R)-methyl-phenyl-phosphinoyl)-9H-xanthene

4,5-dibromo-2,7-di-tert-butyl-9,9-dimethyl-9H-xanthene

methyl(phenyl)chlorophosphine

2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene