2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene

Base Information

• Chemical Name: 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene
• CAS No.: 201226-87-1
• Molecular Formula: C₃₇H₄₄O₃P₂
• Molecular Weight: 598.702
• Mol file: 201226-87-1.mol

Synonyms:2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene

Chemical Property of 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene

There total 1 articles about 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-dibromo-2,7-di-tert-butyl-9,9-dimethyl-9H-xanthene (130525-43-8) + methyl(phenyl)chlorophosphine (15849-86-2,540513-01-7) → 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene (201226-87-1) + 2,7-Di-tert-butyl-9,9-dimethyl-4,5-bis-((R)-methyl-phenyl-phosphinoyl)-9H-xanthene

Guidance literature:

With n-butyllithium; dihydrogen peroxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C, 30 + 30 min, then room temp., 12 h; 2.) THF, H₂O, 0 deg C, then reflux, 2 h;

DOI:10.1016/S0040-4039(97)10363-X

Reference yield: 61.0%

2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene (201226-87-1) → 2,7-Di-tert-butyl-9,9-dimethyl-4,5-bis-((R)-methyl-phenyl-phosphinoyl)-9H-xanthene

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 14h; Ambient temperature; 1.) 0 deg C;

DOI:10.1016/S0040-4039(97)10363-X

Reference yield:

2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphinoyl)-5-((S)-methyl-phenyl-phosphinoyl)-9H-xanthene (201226-87-1) → 2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphanyl)-5-((S)-methyl-phenyl-phosphanyl)-9H-xanthene (201226-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / 1.) LiAlH₄ / tetrahydrofuran / 14 h / Ambient temperature; 1.) 0 deg C

3: titanium tetraisopropoxide, polymethyl hydrosiloxane / tetrahydrofuran / Heating

With titanium(IV) isopropylate; lithium aluminium tetrahydride; polymethyl hydrosiloxane; In tetrahydrofuran;

DOI:10.1016/S0040-4039(97)10363-X

upstream raw materials:

4,5-dibromo-2,7-di-tert-butyl-9,9-dimethyl-9H-xanthene

methyl(phenyl)chlorophosphine

Downstream raw materials:

2,7-Di-tert-butyl-9,9-dimethyl-4-((R)-methyl-phenyl-phosphanyl)-5-((S)-methyl-phenyl-phosphanyl)-9H-xanthene

2,7-Di-tert-butyl-9,9-dimethyl-4,5-bis-((R)-methyl-phenyl-phosphinoyl)-9H-xanthene