3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide

Base Information

Chemical Name:3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide
CAS No.:1181327-51-4
Molecular Formula:C₂₂H₂₁N₅O₃
Molecular Weight:403.44
Hs Code.:
Mol file:1181327-51-4.mol

Synonyms:3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide

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Chemical Property of 3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide

Chemical Property:

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Technology Process of 3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide

There total 4 articles about 3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 832695-88-2
3-(methylcarbamoyl)phenylboronic acid

: 1181329-13-4
6-bromo-N-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine

: 1181327-51-4
3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 135 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm500228a

Reference yield:

: 63744-22-9
6,8-dibromoimidazo[1,2-a]pyrazine

: 1181327-51-4
3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 22 h / 100 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.25 h / 135 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; isopropyl alcohol; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500228a

Reference yield:

: 6315-89-5
3,4-dimethoxyaniline

: 1181327-51-4
3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 22 h / 100 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.25 h / 135 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; isopropyl alcohol; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500228a