(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

Base Information

• Chemical Name: (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
• CAS No.: 1146629-75-5
• Molecular Formula: C12H14ClN3O2
• Molecular Weight: 267.715
• Mol file: 1146629-75-5.mol

Synonyms:(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

Chemical Property of (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

Chemical Property:

• Boiling Point: 390.0±32.0 °C(Predicted)
• PKA: 2.81±0.30(Predicted)
• PSA: 57.01000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 2.63150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methylpivalate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate?can be used as a heterocyclic derivative for pharmaceutical synthesis.

Technology Process of (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

There total 2 articles about (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.85%

Chloromethyl pivalate (18997-19-8) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate (1146629-75-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

Chloromethyl pivalate (18997-19-8) + 4-chloro-7-azaindole (55052-28-3) → (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate (1146629-75-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 100.0%

(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate (1146629-75-5) + 6-(3-nitrophenyl)-1H-indole (1266726-40-2) → (4-(6-(3-nitrophenyl)-1H-indole-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-yl)methyl pivalate (1298084-48-6)

Guidance literature:

With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In 1,4-dioxane; at 120 ℃; for 2h; In a sealed reactor;

upstream raw materials:

Chloromethyl pivalate

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-chloro-7-azaindole

Downstream raw materials:

(4-(6-(3-aminophenyl)-1H-indole-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-yl)methyl pivalate

1-(3-(1-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1H-indole-6-yl)phenyl)-3-(2-methoxyphenyl)urea

N-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-indol-6-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

(4-(6-(3-nitrophenyl)-1H-indole-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-yl)methyl pivalate