1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-yl)pyriMidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-yl)pyriMidine-2,4(1H,3H)-dione
• CAS No.: 84828-97-7
• Molecular Formula: C21H36N2O7Si2
• Molecular Weight: 484.697
• Mol file: 84828-97-7.mol

Synonyms:1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-yl)pyriMidine-2,4(1H,3H)-dione;3',5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-2'-ketouridine;2'-Deoxy-2'-oxo-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]uridine;3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-2'-ketouridine;3',5'-TIPS-2'-ketouridine

Chemical Property of 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-yl)pyriMidine-2,4(1H,3H)-dione

Chemical Property:

• PSA: 108.85000
• LogP: 2.95950

Purity/Quality:

97% ^*data from raw suppliers

1-((6Ar,8R,9Ar)-2,2,4,4-Tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-F][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-yl)pyriMidine-2,4(1H,3H)-dione

There total 13 articles about 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-yl)pyriMidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (69304-38-7) → 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione (84828-97-7)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; at 20 ℃;

Reference yield: 90.0%

1-((2R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-2-phenylselanyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione (288103-32-2) → 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione (84828-97-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 70 ℃;

DOI:10.1016/S0040-4039(00)00432-9

Reference yield: 71.0%

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) + uridine (58-96-8) → 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione (84828-97-7)

Guidance literature:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane; uridine; With 1H-imidazole; In dichloromethane;

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; acetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2019.01.002

upstream raw materials:

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

dimethylsulfide

1-((2R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-2-phenylselanyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Downstream raw materials:

1-((2R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-2-phenylselanyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

1-((2S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-2-phenylselanyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

2'-deoxy-2'-difluoromethylene-5'-dimethoxytrityluridine

[4-¹³C]-(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-trideuteromethyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate