288103-32-2

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 84828-97-7 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 288103-33-3 1-[1-C-Phenylseleno-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribo-pentofuranosyl]uracil 
• 288103-31-1 1-((2S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-2-phenylselanyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione 
• 84828-97-7 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

An efficient method for the preparation of 1′α-branched-chain sugar pyrimidine ribonucleosides from uridine: The first conversion of a natural nucleoside into 1′-substituted ribonucleosides

The 1′α-phenylselenouridine derivative 13 was successfully synthesized by enolization of the 3′,5′-O-TIPDS-2′-ketouridine 8, and was subjected to a radical reaction with a vinylsilyl tether - an efficient procedure for preparing 1′α-branched-chain sugar p

Synthesis of a 1'-α-phenylselenouridine derivative as a synthetic precursor for various 1'-modified nucleosides, via enolization at the 1'- position of 3',5'-O-TIPDS-2'-ketouridine

Synthesis of the 1'-α-phenylselenouridine derivative 1α, a potentially useful precursor for the synthesis of a variety of 1'-modified nucleosides, was achieved via enolization of the 3',5'-O-TIPDS-2'-ketouridine 2. Successive treatment of 2 with LiHMDS and PhSeCl at ≤70°C in THF gave the corresponding 1'-phenylseleno product, which was reduced stereoselectively with NaBH4/CeCl3 in MeOH to give the target compound 1α. (C) 2000 Elsevier Science Ltd.