Technology Process of 1H-Pyrrole-3-carboxylic acid, 5-(2-amino-4-pyrimidinyl)-2-(2,4-dichlorophenyl)-
There total 7 articles about 1H-Pyrrole-3-carboxylic acid, 5-(2-amino-4-pyrimidinyl)-2-(2,4-dichlorophenyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(2-amino-pyrimidin-4-yl)-2-(2,4-dichloro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester;
With
water; sodium hydroxide;
In
1,4-dioxane;
for 8h;
Reflux;
With
hydrogenchloride;
In
1,4-dioxane; water; ethyl acetate;
pH=6;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide / 2 h / 20 °C / Industry scale
1.2: 100 °C / Industry scale
2.1: trifluoroacetic acid / 1 h / 60 °C
2.3: 20 °C
3.1: aluminum (III) chloride / dichloromethane / 0.5 h / 20 °C
4.1: 1,4-dioxane / 12 h / 95 °C
5.1: sodium ethanolate / ethanol / 24 h / Reflux
6.1: sodium hydroxide; water / 1,4-dioxane / 8 h / Reflux
6.2: pH 6
With
water; sodium ethanolate; trifluoroacetic acid; sodium hydroxide;
aluminum (III) chloride;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 20 °C
2.1: 1,4-dioxane / 12 h / 95 °C
3.1: sodium ethanolate / ethanol / 24 h / Reflux
4.1: sodium hydroxide; water / 1,4-dioxane / 8 h / Reflux
4.2: pH 6
With
water; sodium ethanolate; sodium hydroxide;
aluminum (III) chloride;
In
1,4-dioxane; ethanol; dichloromethane;
