4-[[(3-Chloropropoxy)carbonyl]amino]-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[[(3-Chloropropoxy)carbonyl]amino]-benzoic acid methyl ester
• CAS No.: 1031927-07-7
• Molecular Formula: C₁₂H₁₄ClNO₄
• Molecular Weight: 271.7
• Mol file: 1031927-07-7.mol

Synonyms:4-[[(3-Chloropropoxy)carbonyl]amino]-benzoic acid methyl ester;Benzoic acid,4-[[(3-chloropropoxy)carbonyl]amino]-,methyl ester

Chemical Property of 4-[[(3-Chloropropoxy)carbonyl]amino]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[[(3-Chloropropoxy)carbonyl]amino]-benzoic acid methyl ester

There total 1 articles about 4-[[(3-Chloropropoxy)carbonyl]amino]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxycarbonyl aniline (619-45-4) + 3-chloropropyl chloroformate (628-11-5) → C12H14ClNO4 (1031927-07-7)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2007.06.029

Reference yield:

C12H14ClNO4 (1031927-07-7) → C12H13NO4 (1031927-08-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1016/j.bmcl.2007.06.029

Reference yield:

C12H14ClNO4 (1031927-07-7) → C11H11NO4 (766556-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 3 h / 0 °C

2: NaOH / methanol / 20 - 50 °C

With sodium hydroxide; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2007.06.029

upstream raw materials:

4-methoxycarbonyl aniline

3-chloropropyl chloroformate

Downstream raw materials:

C₁₂H₁₃NO₄

C₁₁H₁₁NO₄