6β-Methoxy-3β,5α-cyclo-33-norgorgost-24(28)-ene

Base Information

Chemical Name:6β-Methoxy-3β,5α-cyclo-33-norgorgost-24(28)-ene
CAS No.:55064-59-0
Molecular Formula:
Molecular Weight:424.7
Hs Code.:
Mol file:55064-59-0.mol

Synonyms:6β-Methoxy-3β,5α-cyclo-33-norgorgost-24(28)-ene

Suppliers and Price of 6β-Methoxy-3β,5α-cyclo-33-norgorgost-24(28)-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of 6β-Methoxy-3β,5α-cyclo-33-norgorgost-24(28)-ene

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 6β-Methoxy-3β,5α-cyclo-33-norgorgost-24(28)-ene

There total 42 articles about 6β-Methoxy-3β,5α-cyclo-33-norgorgost-24(28)-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10211-88-8
(20S)-3β-acetoxybisnorchol-5-en-22-al

: 55064-59-0,71424-80-1
3α,5-cyclo-22,23-methanato-24-methylene-6β-methoxy-5α-cholestane

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) Mg / 1.) THF, -18 deg C, 1 h; 2.) THF, -18 deg C, 3 h

2: 12.6 g / pyridine / 1 h / Ambient temperature

3: 1.) N-methylmorpholine oxide, osmium tetroxide; 2.) NaHSO₃ / 1.) THF/t-BuOH/H₂O, r.t., 2 h; 2.) THF/t-BuOH/H₂O, r.t., 1 h

4: 12.1 g / sodium metaperiodate / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature

5: t-BuOK / tetrahydrofuran / 0.33 h / 0 °C

6: 1.) Mg / 1.) THF, r.t., 1 h; 2.) THF, -18 deg C, 2 h

7: 2.50 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

8: 1.) n-BuLi / 1.) THF, r.t., 30 min; 2.) THF, r.t., 18 h

9: pyridine

10: 508 mg / KOAc / 3 h / Heating

With pyridine; sodium periodate; osmium(VIII) oxide; n-butyllithium; potassium tert-butylate; potassium acetate; sodium hydrogensulfite; magnesium; 4-methylmorpholine N-oxide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1248/cpb.29.406

Reference yield:

: 10211-88-8
(20S)-3β-acetoxybisnorchol-5-en-22-al

: 55064-59-0,71424-80-1
(1aR,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-6-{(R)-1-[(1S,2R)-2-(2-methyl-1-methylene-propyl)-cyclopropyl]-ethyl}-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene

Guidance literature:: Multi-step reaction with 14 steps

1: 1.) n-BuLi / 1.) hexane, THF, r.t., 5 min; 2.) hexane, THF, r.t., 30 min

2: pyridine / 2 h / Ambient temperature

3: 6.2 g / 2N H₂SO₄ / dioxane / 0.5 h / 70 °C

4: benzene / 1.5 h / Heating

5: 2.) water / 1.) benzene, reflux, 45 h; 2.) benzene, reflux, 30 min

6: NaBH₄ / ethanol; tetrahydrofuran / 1 h / 0 °C

7: pyridine / Ambient temperature

8: 1.) N-methylmorpholine oxide, osmium tetroxide; 2.) NaHSO₃ / 1.) THF/t-BuOH/H₂O, r.t. ; 2.) THF/t-BuOH/H₂O, r.t.

9: sodium metaperiodate / tetrahydrofuran; H₂O / Ambient temperature

10: 80 percent / t-BuOK / diethyl ether / Ambient temperature

11: 1.) Mg; 3.) pyridinium chlorochomate / 1.) THF, r.t.; 2.) THF, -18 deg C; 3.) CH₂Cl₂, r.t.

12: 1.) n-BuLi / 1.) THF, r.t.; 2.) THF, r.t.

13: pyridine

14: KOAc / Heating

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; n-butyllithium; sulfuric acid; potassium tert-butylate; water; potassium acetate; sodium hydrogensulfite; magnesium; 4-methylmorpholine N-oxide; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; benzene;
DOI:10.1248/cpb.29.406

Reference yield:

: 78873-43-5
3β-(Tetrahydropyranyloxy)-22-iodo-23,24-bisnorchol-5-ene

: 55064-59-0,71424-80-1
(1aR,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-6-{(R)-1-[(1S,2R)-2-(2-methyl-1-methylene-propyl)-cyclopropyl]-ethyl}-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene

Guidance literature:: Multi-step reaction with 14 steps

1: 9.24 g / n-BuLi / hexane; tetrahydrofuran / 1.) -18 deg C, 2 h; 2.) r.t., 24 h

2: HgCl₂ / acetonitrile; H₂O / 2 h / Heating

3: pyridine / 3 h / 70 °C

4: benzene / 1.5 h / Heating

5: 2.) water / 1.) benzene, reflux, 45 h; 2.) benzene, reflux, 30 min

6: NaBH₄ / ethanol; tetrahydrofuran / 1 h / 0 °C

7: pyridine / Ambient temperature

8: 1.) N-methylmorpholine oxide, osmium tetroxide; 2.) NaHSO₃ / 1.) THF/t-BuOH/H₂O, r.t. ; 2.) THF/t-BuOH/H₂O, r.t.

9: sodium metaperiodate / tetrahydrofuran; H₂O / Ambient temperature

10: 80 percent / t-BuOK / diethyl ether / Ambient temperature

11: 1.) Mg; 3.) pyridinium chlorochomate / 1.) THF, r.t.; 2.) THF, -18 deg C; 3.) CH₂Cl₂, r.t.

12: 1.) n-BuLi / 1.) THF, r.t.; 2.) THF, r.t.

13: pyridine

14: KOAc / Heating

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; n-butyllithium; potassium tert-butylate; water; potassium acetate; sodium hydrogensulfite; magnesium; 4-methylmorpholine N-oxide; pyridinium chlorochromate; mercury dichloride; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; acetonitrile; benzene;
DOI:10.1248/cpb.29.406