Z-Pro-val-OH

Base Information

Chemical Name:Z-Pro-val-OH
CAS No.:21285-27-8
Molecular Formula:C18H24 N2 O5
Molecular Weight:348.399
Hs Code.:
European Community (EC) Number:244-312-7
Nikkaji Number:J226.179K
Mol file:21285-27-8.mol

Synonyms:Z-PRO-VAL-OH;21285-27-8;NSC153411;N-CBZ-L-prolyl-L-valine;SCHEMBL7315812;EINECS 244-312-7;N-Benzyloxycarbonyl-L-Prolyl-L-Valine;NSC 153411;(2S)-3-methyl-2-[[(2S)-1-phenylmethoxycarbonylpyrrolidine-2-carbonyl]amino]butanoic acid;N-(1-((Benzyloxy)carbonyl)-L-prolyl)-L-valine;L-Valine, 1-[(phenylmethoxy)carbonyl]-L-prolyl-;N-[1-[(Phenylmethoxy)carbonyl]-L-prolyl]-L-valine;(2S)-2-[[(2S)-1-benzyloxycarbonylpyrrolidine-2-carbonyl]amino]-3-methyl-butanoic acid;(S)-2-((S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido)-3-methylbutanoic acid

Suppliers and Price of Z-Pro-val-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of Z-Pro-val-OH

Chemical Property:

Vapor Pressure:1.27E-14mmHg at 25°C
Boiling Point:587°Cat760mmHg
Flash Point:308.8°C
PSA：95.94000
Density:1.246g/cm³
LogP:2.34180
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:348.16852187
Heavy Atom Count:25
Complexity:488

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)O)NC(=O)C1CCCN1C(=O)OCC2=CC=CC=C2
Isomeric SMILES:CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)OCC2=CC=CC=C2

Technology Process of Z-Pro-val-OH

There total 14 articles about Z-Pro-val-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 886981-23-3
benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 21285-27-8
(2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]-3-methylbutanoic acid

Guidance literature:: With triethylamine; In water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jo0704255

Reference yield: 85.0%

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: Z-Pro-OBt

: 21285-27-8
(2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]-3-methylbutanoic acid

Guidance literature:: Z-Pro-OBt; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

L-valine; With sodium perchlorate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;