benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate

Base Information

• Chemical Name: benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate
• CAS No.: 886981-23-3
• Molecular Formula: C₁₉H₁₈N₄O₃
• Molecular Weight: 350.377

Synonyms:benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate

Chemical Property of benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate

There total 1 articles about benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate (886981-23-3)

Guidance literature:

1,2,3-Benzotriazole; With thionyl chloride; In tetrahydrofuran; at 20 ℃; for 0.333333h;

N-Benzyloxycarbonyl-L-proline; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1002/chem.201304262

Reference yield: 98.0%

benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate (886981-23-3) + 2-Amino-4-methylpyridine (695-34-1) → benzyl (2S)-2-[(4-methyl-2-pyridinyl)amino]carbonyl-tetrahydro-1H-pyrrole-1-carboxylate

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 0.5h; microwave irradiation;

DOI:10.1021/jo8007379

Reference yield: 95.0%

benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate (886981-23-3) + L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]-3-methylbutanoic acid (21285-27-8)

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/jo0704255

upstream raw materials:

1,2,3-Benzotriazole

N-Benzyloxycarbonyl-L-proline

Downstream raw materials:

(2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]propanoic acid

(2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]-3-methylbutanoic acid

(S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-3-phenylpropanoic acid

(2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]-4-(methylsulfanyl)butanoic acid

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