2-(5-Chloro-2-hydroxyphenyl)-4(3)-quinazolone

Base Information

• Chemical Name: 2-(5-Chloro-2-hydroxyphenyl)-4(3)-quinazolone
• CAS No.: 1151-84-4
• Molecular Formula: C14H9ClN2O2
• Molecular Weight: 272.691
• Hs Code.: 2933990090
• Mol file: 1151-84-4.mol

Synonyms:2-(5-Chloro-2-hydroxyphenyl)-4(3H)-quinazolone;2-(5-Chloro-2-hydroxyphenyl)quinazolin-4(3H)-one;4(3H)-Quinazolinone, 2-(5-chloro-2-hydroxyphenyl)

Chemical Property of 2-(5-Chloro-2-hydroxyphenyl)-4(3)-quinazolone

Chemical Property:

• Boiling Point: 476.9±55.0 °C(Predicted)
• PKA: 7.54±0.48(Predicted)
• PSA: 65.98000
• Density: 1.46±0.1 g/cm3(Predicted)
• LogP: 2.94910

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(5-Chloro-2-hydroxyphenyl)-4(3)-quinazolone

There total 5 articles about 2-(5-Chloro-2-hydroxyphenyl)-4(3)-quinazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(2-hydroxy-5-chlorobenzylideneamino)benzamide → 2-(2-hydroxy-5-chlorophenyl)–3H-quinazolin-4-one (1151-84-4)

Guidance literature:

With copper dichloride; In ethanol; for 2h; Reflux;

DOI:10.1016/j.saa.2021.119497

Reference yield:

anthranilic acid amide (28144-70-9,88-68-6) → 2-(2-hydroxy-5-chlorophenyl)–3H-quinazolin-4-one (1151-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 5 h / 20 °C

2: copper dichloride / ethanol / 2 h / Reflux

With copper dichloride; In ethanol;

DOI:10.1016/j.saa.2021.119497

Reference yield:

5-chlorosalicyclaldehyde (635-93-8) → 2-(2-hydroxy-5-chlorophenyl)–3H-quinazolin-4-one (1151-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 5 h / 20 °C

2: copper dichloride / ethanol / 2 h / Reflux

With copper dichloride; In ethanol;

DOI:10.1016/j.saa.2021.119497

upstream raw materials:

anthranilic acid amide

5-chlorosalicyclaldehyde