5-(4-FLUOROPHENYL)-5-OXOVALERONITRILE

Base Information

• Chemical Name: 5-(4-FLUOROPHENYL)-5-OXOVALERONITRILE
• CAS No.: 898767-06-1
• Molecular Formula: C11H10FNO
• Molecular Weight: 191.2
• Hs Code.: 2926909090
• Mol file: 898767-06-1.mol

Synonyms:5-(4-FLUOROPHENYL)-5-OXOVALERONITRILE

Chemical Property of 5-(4-FLUOROPHENYL)-5-OXOVALERONITRILE

Chemical Property:

• Vapor Pressure: 3.14E-05mmHg at 25°C
• Boiling Point: 355.4°C at 760 mmHg
• Flash Point: 168.7°C
• PSA: 40.86000
• Density: 1.137g/cm³
• LogP: 2.70228

Purity/Quality:

97% ^*data from raw suppliers

5-(4-Fluorophenyl)-5-oxovaleronitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-FLUOROPHENYL)-5-OXOVALERONITRILE

There total 12 articles about 5-(4-FLUOROPHENYL)-5-OXOVALERONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(4-fluorophenyl)cyclopentan-1-one O-(4-(trifluoromethyl)benzoyl)oxime → 5-(4-fluorophenyl)-5-oxopentanenitrile (898767-06-1)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); dimethyl sulfoxide; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;

DOI:10.1002/cjoc.201800206

Reference yield: 72.0%

ethyl 4-cyano-2-(4-fluorobenzoyl)butanoate (1402927-10-9) → 5-(4-fluorophenyl)-5-oxopentanenitrile (898767-06-1)

Guidance literature:

With sodium carbonate; In water; for 12 - 15h; Reflux;

DOI:10.1002/anie.201204469

Reference yield: 59.0%

Glutaronitrile (544-13-8) + 4-fluoroboronic acid (1765-93-1) → 5-(4-fluorophenyl)-5-oxopentanenitrile (898767-06-1)

Guidance literature:

With [2,2]bipyridinyl; palladium(II) acetylacetonate; toluene-4-sulfonic acid; In water; toluene; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1021/acs.joc.9b02999

upstream raw materials:

potassium cyanide

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

ethyl 4-cyano-2-(4-fluorobenzoyl)butanoate

ethyl 3-(4'-fluorophenyl)-3-oxopropionate

Downstream raw materials:

(S)-2-(4-fluorophenyl)-2-hydroxycyclopentanone

2-(4-fluorophenyl)-6-phenylpyridine

2-(4-fluoro-phenyl)-tetrahydro-furan-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 898767-06-1 5-(4-FLUOROPHENYL)-5-OXOVALERONITRILE

Send

Send

Metric Ton KG G Pound L ML

Send

Send