1-(4-BroMo-3-Methoxyphenyl)ethanone

Base Information

• Chemical Name: 1-(4-BroMo-3-Methoxyphenyl)ethanone
• CAS No.: 50870-44-5
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.073
• Hs Code.: 2914700090
• Mol file: 50870-44-5.mol

Synonyms:1-(4-BroMo-3-Methoxyphenyl)ethanone;1-(4-bromo-3-methoxyphenyl)ethan-1-one

Chemical Property of 1-(4-BroMo-3-Methoxyphenyl)ethanone

Chemical Property:

• Melting Point: 31.5-32.0 °C
• Boiling Point: 292.7±25.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.421±0.06 g/cm3(Predicted)
• LogP: 2.66030
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4'-Bromo-3'-methoxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BroMo-3-Methoxyphenyl)ethanone

There total 3 articles about 1-(4-BroMo-3-Methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-3-methoxyaniline (19056-40-7) + sodium acetate (127-09-3) → 1-(4-bromo-3-methoxyphenyl)ethanone (50870-44-5)

Guidance literature:

4-bromo-3-methoxyaniline; With hydrogenchloride; sodium nitrite; In water; at -5 - 0 ℃; for 1h;

sodium acetate; With Acetaldehyde oxime; copper(II) sulfate; In water; at 0 - 10 ℃; for 2h;

With hydrogenchloride; In water; for 2h; Reflux;

Reference yield:

4-bromo-3-methoxy-benzoyl chloride (56256-15-6) + methyllithium (917-54-4) → 1-(4-bromo-3-methoxyphenyl)ethanone (50870-44-5)

Guidance literature:

methyllithium; With copper(l) iodide; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 - 0 ℃; for 0.333333h;

4-bromo-3-methoxy-benzoyl chloride; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 ℃; for 0.666667h;

DOI:10.1021/jm8009124

Reference yield:

→ 1-(4-bromo-3-methoxyphenyl)ethanone (50870-44-5)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

4-bromo-3-methoxy-benzoyl chloride

methyllithium

4-bromo-3-methoxyaniline

sodium acetate

Downstream raw materials:

2,4,6-tris(3-methoxy-4-bromophenyl)pyridine

4-bromo-3-methoxy-benzoic acid

Refernces

• 1、 -. "ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". Paragraph 0260; 0261; 0262; 0263. . Retrieved 2017/06/12.