127-09-3

Basic information

• Product Name: Sodium acetate
• Synonyms: SODIUM ACETATE ANHYDROUS CELL CULTUR;Sodium acetate anhydrous for analysis EMSURE ACS,Reag. Ph Eur;SODIUM ACETATE ANHYDROUS, FOR MOLECU;Sodium acetate anhydrous, free-flowing, Redi-Dri, ACS reagent, >=99.0%;SODIUM ACETATE BIOXTRA;SODIUM ACETATE SOLUTION, F. MOL. BIO;SODIUM ACETATE, ANHYDROUS, FOR&;Sodium acetate, anhydrousACS/USP/FCC, 99.0-101.0% (Titration: after drying)
• CAS NO: 127-09-3
• Molecular Formula: C₂H₃O₂*Na
• Molecular Weight: 82.03379
• EINECS: 204-823-8
• Product Categories: Food Additives;INORGANIC & ORGANIC CHEMICALS;Other Buffer SolutionsSynthetic Reagents;Buffer Convenience Packaging;Buffer Solutions;Buffer SolutionsBiological Buffers;Buffers A to ZpH Buffers for Titration;Inorganic Salts;AlphabeticalMolecular Biology;Biological Buffers;BioUltra Buffers;BioUltraBiological Buffers;Buffer SolutionsProtein Structural Analysis;DNA&RNA Purification;Molecular Biology Reagents;Optimization ReagentsMolecular Biology;Reagents;X-Ray Crystallography;Alphabetical Listings;Flavors and Fragrances;Q-Z;metal acetate salt;Auxiliary or oragnic intermediates;Food additive
• Mol File: 127-09-3.mol
• Article Data: 196

Chemical Properties

• Melting Point: >300 °C (dec.)(lit.)
• Boiling Point: 117.1 °C at 760 mmHg
• Flash Point: >250 °C
• Appearance: white/powder
• Density: 1.01 g/mL at 20 °C
• Vapor Pressure: 13.9mmHg at 25°C
• Refractive Index: 1.4640
• Storage Temp.: 2-8°C
• Solubility: H2O: 3 M at 20 °C, clear, colorless
• PKA: 4.756[at 20 ℃]
• Water Solubility: 500 g/L (20 ºC)
• Sensitive: Hygroscopic
• Stability: Stable. Incompatible with strong oxidizing agents, halogens. Moisture sensitive.
• Merck: 14,8571
• BRN: 3595639
• CAS DataBase Reference: Sodium acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium acetate(127-09-3)
• EPA Substance Registry System: Sodium acetate(127-09-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 1
• RTECS: AJ4300010
• F: 3
• TSCA: Yes
• Hazardous Substances Data: 127-09-3(Hazardous Substances Data)

Usage

Chemical Description

Different sources of media describe the Chemical Description of 127-09-3 differently. You can refer to the following data:
1. Sodium acetate is a salt commonly used as a buffer in biochemistry.
2. Sodium acetate is a salt commonly used in the textile industry.
3. Sodium acetate is a white crystalline powder that is used in the textile industry.

Description

Sodium acetate (CH3COONa) is the sodium salt of acetic acid. It appears as a colorless deliquescent salt with a wide range of applications. In industry, it can be used in textile industry to neutralize sulfuric acid waste streams and as a photoresist upon using aniline dyes. In concrete industry, it can be used as a concrete sealant to mitigate the water damage. In food, it can be used as a seasoning. It can also be used as a buffer solution in lab. In addition, it is also used in heating pads, hand warmers and hot ice. For laboratory use, it can be produced by the reaction between acetate with the sodium carbonate, sodium bicarbonate and sodium hydroxide. In industry, it is prepared from the glacial acetic acid and sodium hydroxide.

Chemical Properties

Different sources of media describe the Chemical Properties of 127-09-3 differently. You can refer to the following data:
1. Anhydrous salt is a colorless crystalline solid; density 1.528 g/cm3; melts at 324°C; very soluble in water; moderately soluble in ethanol. The colorless crystalline trihydrate has a density 1.45 g/cm3; decomposes at 58°C; is very soluble in water; pH of 0.1M aqueous solution is 8.9; moderately soluble in ethanol, 5.3 g/100mL.
2. Sodium acetate, CH3COONa, also abbreviated NaOAc , also sodium ethanoate, is the sodium salt of acetic acid, was made by the reaction of acetic acid with sodium carbonate. It is soluble in water but less so in alcohol. This colourless salt has a wide range of uses. Sodium acetate was used as a pH modifier for toning baths.
3. Sodium acetate is odorless or has a faint acetous odor. It effloresces in warm, dry air.

Physical properties

Anhydrous salt is a colorless crystalline solid; density 1.528 g/cm3; melts at 324°C; very soluble in water; moderately soluble in ethanol. The colorless crystalline trihydrate has a density 1.45 g/cm3; decomposes at 58°C; is very soluble in water; pH of 0.1M aqueous solution is 8.9; moderately soluble in ethanol, 5.3 g/100mL.

Occurrence

Acetic acid or acetates are present in most plant and animal tissues in small, but detectable amounts

Uses

Different sources of media describe the Uses of 127-09-3 differently. You can refer to the following data:
1. Sodium Acetate, Anhydrous is a source of acetic acid obtained as a granular powder. it has a solubility of 1 g in 2 ml of water.
2. Sodium acetate is a mordant in dyeing. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution. Sodium acetate can be used to preserve processed meats and it is often used in combination with other acid based preservatives like lactates and propionates. The typical inclusion level is 0.2 to 0.5%. Sodium acetate is also used in salad dressings and ready-to-eat meals.
3. Used as buffers. Acidity regulation (buffering) Sodium acetate mixed with acetic acid forms a pH buffer, which can be used to stabilise the pH of foods in the pH-range from 3 to 6. The table below gives indicative values of the composition needed to give a certain pH. The mixtures below can be diluted at least 10 times with minimum effect on pH, however, the stability decreases.

Preparation

Sodium acetate is prepared by reacting sodium hydroxide or sodium carbonate with acetic acid in aqueous solution. The solution is evaporated to obtain hydrated crystals of sodium acetate. NaOH + CH3COOH → CH3COONa + H2O Na2CO3 + CH3COOH → 2CH3COONa + CO2 + H2O

Definition

A white solid prepared by the neutralization of ethanoic acid with either sodium carbonate or sodium hydroxide. Sodium ethanoate reacts with sulfuric acid to form sodium hydrogensulfate and ethanoic acid; with sodium hydroxide it gives rise to sodium carbonate and methane. Sodium ethanoate is used in the dyeing industry.

Application

2 - 1 - Industrial Sodium acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. It is also a pickling agent in chrome tanning, and it helps to retard vulcanization of chloroprene in synthetic rubber production. In processing cotton for disposable cotton pads, sodium acetate is used to eliminate the buildup of static electricity. 2 - 2 - Concrete longevity Sodium acetate is used to reduce the damage water can potentially do to concrete by acting as a concrete sealant, while also being environmentally benign and cheaper than the epoxy alternative that is usually employed for sealing concrete against water permeation. 2 - 3 - Food Sodium acetate may be added to foods as a seasoning. It may be used in the form of sodium diacetate — a 1:1 complex of sodium acetate and acetic acid, given the E-number E262. A frequent use is to impart a salt and vinegar flavor to potato chips. 2 - 4 - Buffer solution As the conjugate base of acetic acid, a solution of sodium acetate and acetic acid can act as a buffer to keep a relatively constant pH. 2 - 5 - Heating pad Sodium acetate is also used in consumer heating pads or hand warmers and is also used in hot ice. Sodium acetate trihydrate crystals melt at 58.4°C , (to 58°C ) dissolving in their water of crystallization. When they are heated to around 100°C, and subsequently allowed to cool, the aqueous solution becomes supersaturated. This solution is capable of cooling to room temperature with out forming crystals.

Synthesis

Different sources of media describe the Synthesis of 127-09-3 differently. You can refer to the following data:
1. For laboratory use, sodium acetate is very inexpensive, and is usually purchased instead of being synthesized. It is sometimes produced in a laboratory experiment by the reaction of acetic acid (ethanoic acid) with sodium carbonate, sodium bicarbonate, or sodium hydroxide. These reactions produce aqueous sodium acetate and water. Carbon dioxide is produced in the reaction with sodium carbonate and bicarbonate, and it leaves the reaction vessel as a gas (unless the reaction vessel is pressurized). This is the well-known "volcano" reaction between baking soda (sodium bicarbonate) and vinegar. CH3COOH + NaHCO3 → CH3COONa + H2O + CO2 Industrially, sodium acetate is prepared from glacial acetic acid and sodium hydroxide. CH3COOH + NaOH → CH3COONa + H2O.
2. Acetic acid plus sodium bicarbonate makes sodium acetate plus carbonic acid. Produced by the neutralization of acetic acid with sodium bicarbonate, or by treating calcium acetate with sodium sulfate and sodium bicarbonate.

Reactions

Sodium acetate can be used to form an ester with an alkyl halide such as bromo ethane: CH3COONa + Br CH2CH3→ CH3COOCH2CH3+ NaBr Caesium salts catalyze this reaction.

General Description

Sodium Acetate is reported to inhibit the growth of Listeria monocytogenes.

Reactivity Profile

When sodium acetate reacts with strong acids, irritating, noxious vapors of acetic acid are usually produced. Sodium acetate is sufficiently basic to catalyze the violent polymerization of diketene, perhaps as well as other reactive dimers that are susceptible to polymerization in the presence of a mild base.

Flammability and Explosibility

Nonflammable

Biological Activity

Commonly used laboratory reagent

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion. A skin and eye irritant. Migrates to food from packagmg materials. Violent reaction with F2, m03, diketene. When heated to decomposition it emits toxic fumes of Na2O.

Purification Methods

Crystallise it from acetic acid and keep it under vacuum for 10hours at 120o. Alternatively, it is crystallised from aqueous EtOH, as the trihydrate. This material can be converted to anhydrous salt by heating slowly in a porcelain, nickel or iron dish, so that the salt liquefies. Steam is evolved and the mass again solidifies. Heating is now increased so that the salt melts again. (NB: if it is heated too strongly, the salt can char; avoid this.) After several minutes, the salt is allowed to solidify and is cooled to a convenient temperature (in a desiccator) before being powdered and bottled. The water content should now be less than 0.02%. [Beilstein 2 II 113, 2 III 184, 2 IV 109.]

InChI:InChI=1/C2H4O2.Na.3H2O/c1-2(3)4;;;;/h1H3,(H,3,4);;3*1H2/q;+1;;;/p-1

Synthetic route

sodium amidotrihydridoborate (148977-74-6) + acetic acid (64-19-7) → ammonia borane complex (10043-11-5) + sodium acetate (127-09-3)

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	A 92% B n/a

acetic acid (64-19-7) → sodium acetate (127-09-3)

Conditions	Yield
With sodium methylate In methanol at 20℃;	91.85%
With KB-4P-2(Na) Equilibrium constant; exchange equilibrium constant;
With [D]-sodium hydroxide In water-d2 at 22.9℃;
With sodium methylate In methanol

sodium 2-oxopropane-1-sulfonate (16562-77-9) → sodium acetate (127-09-3) + methanesulfonic acid sodium salt (2386-57-4)

Conditions	Yield
With sodium hydroxide In water for 6h; Heating;	A 84% B 32%

Na5(IMo6O24)*99H2O + cobalt(II) diacetate tetrahydrate (6147-53-1) → Na3Co(IMo6O24)*14H2O + sodium acetate (127-09-3)

Conditions	Yield
With CH3COOH In water addn. of Co(OAc)2 to slurry of Mo salt, pH adjusted to 6 (HOAc), stirring (5 min), hot filtration, crystn. on slow evapn.; elem. anal.;	A 83% B n/a

sodium hydroxide (1310-73-2) + acetylene (74-86-2) → sodium acetate (127-09-3)

Conditions	Yield
With hydrogen In sodium hydroxide addn. of 4% C2H2/H2 mixt. to 20% aq. NaOH under pressure at 220-230°C;;	70%
With hydrogen In sodium hydroxide addn. of 4% C2H2/H2 mixt. to 20% aq. NaOH under pressure at 220-230°C;;	70%

sodium azide + 1,4-bis(imidazol-l-yl-methyl)benzene (56643-83-5) + cobalt(II) acetate (71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7) → 2Co(2+)*3C3H3N2CH2C6H4CH2N2H3C3*4N3(1-)*6H2O=Co2(C3H3N2CH2C6H4CH2N2H3C3)3(N3)4*6H2O + sodium acetate (127-09-3)

Conditions	Yield
In methanol; water mixing of soln. of org.ligand in MeOH and soln. of M(OAc)2 in water, addn. of soln. of NaN3 in water, stirring (room temp., 10 min; pptn.); stirring (6 h), filtration, washing water, MeOH, ether), drying (vac.); elem. anal.;	A 66.2% B n/a

Na5(IMo6O24)*99H2O + copper(II) acetate monohydrate (6046-93-1) → Na3Cu(IMo6O24)*9H2O + sodium acetate (127-09-3)

Conditions	Yield
With CH3COOH In water addn. of Co(OAc)2 to slurry of Mo salt, pH adjusted to 6 (HOAc), stirring (5 min), hot filtration, crystn. on slow evapn.; elem. anal.;	A 65% B n/a

sodium azide + nickel diacetate (373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6) + 1,4-bis(imidazol-1-ylmethyl)-2,5-dimethylbenzene → 2Ni(2+)*3C3H3N2CH2C6H2(CH3)2CH2N2H3C3*4N3(1-)*4H2O=Ni2(C3H3N2CH2C6H2(CH3)2CH2N2H3C3)3(N3)4*4H2O + sodium acetate (127-09-3)

Conditions	Yield
In methanol; water mixing of soln. of org.ligand in MeOH and soln. of M(OAc)2 in water, addn. of soln. of NaN3 in water, stirring (room temp., 10 min; pptn.); stirring (6 h), filtration, washing water, MeOH, ether), drying (vac.); elem. anal.;	A 63.8% B n/a

acetamide (60-35-5) → 4,5-bis(aminomethyl)-3,6-bis(1-aminovinyl)cyclohexa-3,5-diene-1,2-dione (1198018-65-3) + sodium acetate (127-09-3)

Conditions	Yield
Stage #1: acetamide With sulfur dioxide; water at -15℃; Stage #2: With water; sodium carbonate at -10 - -5℃;	A 62% B n/a

sodium azide + 1,4-bis(imidazol-l-yl-methyl)benzene (56643-83-5) + nickel diacetate (373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6) → 2Ni(2+)*3C3H3N2CH2C6H4CH2N2H3C3*4N3(1-)*6H2O=Ni2(C3H3N2CH2C6H4CH2N2H3C3)3(N3)4*6H2O + sodium acetate (127-09-3)

Conditions	Yield
In methanol; water mixing of soln. of org.ligand in MeOH and soln. of M(OAc)2 in water, addn. of soln. of NaN3 in water, stirring (room temp., 10 min; pptn.); stirring (6 h), filtration, washing water, MeOH, ether), drying (vac.); elem. anal.;	A 56.8% B n/a

sodium azide + manganese(II) acetate (638-38-0, 993-02-2, 2180-18-9, 15411-95-7, 22981-23-3, 27004-39-3) + 1,4-bis(imidazol-1-ylmethyl)-2,5-dimethylbenzene → 2Mn(2+)*3C3H3N2CH2C6H2(CH3)2CH2N2H3C3*4N3(1-)*6H2O=Mn2(C3H3N2CH2C6H2(CH3)2CH2N2H3C3)3(N3)4*6H2O + sodium acetate (127-09-3)

Conditions	Yield
In methanol; water mixing of soln. of org.ligand in MeOH and soln. of M(OAc)2 in water, addn. of soln. of NaN3 in water, stirring (room temp., 10 min; pptn.); stirring (6 h), filtration, washing water, MeOH, ether), drying (vac.); elem. anal.;	A 56.7% B n/a

Upstream product

• 497-19-8 Sodium carbonate 
• 62-54-4 Calcium acetate 
• 6131-90-4 Sodium acetate trihydrate 

Downstream Products

• 56602-33-6 Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate 
• 33024-60-1 4-Aminotetrahydropyran hydrochloride 
• 93680-80-9 3-Acetoxybenzofuran 
• 194-59-2 7H-DIBENZO[C,G]CARBAZOLE 
• 1664-57-9 3-(3-Nitrophenyl)propionic acid 
• 149771-12-0 ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate 
• 59290-85-6 3-NITRO-PYRIDINE-2-CARBOXYLIC ACID 
• 32585-08-3 METHYL2-HEXENOATE 
• 286-62-4 CYCLOOCTENE OXIDE 
• 103-54-8 Cinnamyl acetate 
• 104-21-2 Anisyl acetate 
• 10551-58-3 5-ACETOXYMETHYL-2-FURALDEHYDE 
• 60-11-7 Solvent Yellow 2 
• 59-82-5 5-NITRO-2-FURONITRILE 
• 150-84-5 Citronellyl acetate 
• 119-75-5 2-Nitrodiphenylamine 
• 126-96-5 Sodium diacetate 
• 2555-37-5 3-acetyl-4-hydroxy-2-benzopyrone 
• 2623-23-6 (1R)-(-)-Menthyl acetate 
• 7234-25-5 4-METHYL-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 
• 3861-73-2 ACID BLUE 92 
• 1328-25-2 Vat Black 9 
• 80-26-2 Terpinyl acetate 
• 81-23-2 Dehydrocholic acid 
• 947-02-4 PHOSFOLAN 
• 573-20-6 Menadiol diacetate 
• 15371-15-0 CHEMBRDG-BB 4023079 
• 932-53-6 6-AZATHYMINE 
• 89-48-5 Menthyl acetate 
• 306936-57-2 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 
• 50847-11-5 Ibudilast 
• 51364-51-3 Tris(dibenzylideneacetone)dipalladium 
• 1271-47-2 ETHYNYLFERROCENE 
• 5271-38-5 2-(METHYLTHIO)ETHANOL 
• 2164-61-6 3-Pyridazinecarboxylic acid 
• 1173-88-2 OXACILLIN SODIUM 
• 141505-33-1 Levosimendan 
• 3423-25-4 endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol 
• 9035-81-8 Trypsin inhibitor 

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• 1180-34-3  podophyllotoxinyl acetate 
• 108-24-7  acetic anhydride 
• 70774-92-4  methyl 4,6-O-benzylidene-2-O-p-toluenesulphonyl-α-D-glucopyranoside 
• 120200-47-7  methyl-[O³-benzoyl-O⁴,O⁶-((R)-benzylidene)-O²-(toluene-4-sulfonyl)-α-D-glucopyranoside] 
• 109-86-4  2-methoxy-ethanol 
• 109-83-1  (2-hydroxyethyl)(methyl)amine 
• 47192-97-2  3,6-Dimethoxy-4-acetoxyphenanthrene 
• 115-37-7  (+-)-thebaine 
• 542-59-6  2-hydroxyethyl acetate 
• 75-21-8  oxirane 
• 5371-52-8  2-hydroxytetrahydrofuran 
• 109-99-9  tetrahydrofuran 
• 100-34-5  benzene diazonium chloride 

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