5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester
• CAS No.: 223690-43-5
• Molecular Formula: C₁₂H₉F₂NO₃
• Molecular Weight: 253.205
• Hs Code.: 2933499090
• Mol file: 223690-43-5.mol

Synonyms:5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester

Chemical Property of 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 8.44E-05mmHg at 25°C
• Boiling Point: 340.7°C at 760 mmHg
• Flash Point: 159.9°C
• PSA: 59.16000
• Density: 1.386g/cm³
• LogP: 1.98300

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester

There total 8 articles about 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

diethyl 2-(((2,5-difluorophenyl)amino)methylene)malonate (185010-73-5) → ethyl 5,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (185011-67-0,223690-43-5)

Guidance literature:

With Eaton's reagent; at 90 - 100 ℃; Inert atmosphere;

DOI:10.1021/jm400540b

Reference yield: 65.0%

ethyl 5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate (1203711-96-9) → 5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1203712-03-1) + ethyl 5,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (185011-67-0,223690-43-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 2h; Reflux;

DOI:10.1021/jm400540b

Reference yield: 65.0%

diethyl 2-(((2,5-difluorophenyl)amino)methylene)malonate (185010-73-5) → ethyl 5,8-difluoro-4-hydroxy-3-quinolinecarboxylate (185011-67-0,223690-43-5)

Guidance literature:

In diphenylether; at 250 ℃; for 1h;

DOI:10.1016/S0022-1139(98)00310-8

upstream raw materials:

diethyl 2-(((2,5-difluorophenyl)amino)methylene)malonate

2,5-difluoroaniline

diethyl 2-ethoxymethylenemalonate

ethyl 5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

Downstream raw materials:

C₁₉H₁₄BrF₂NO₃

ethyl 1-([1,1′-biphenyl]-2-ylmethyl)-5,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

ethyl 1-([1,1′-biphenyl]-3-ylmethyl)-5,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

5,8-difluoro-1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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