4-((tert-butyldimethylsilyloxy)methyl)-2,6-dichloropyridine

Base Information

Chemical Name:4-((tert-butyldimethylsilyloxy)methyl)-2,6-dichloropyridine
CAS No.:221095-71-2
Molecular Formula:C₁₂H₁₉Cl₂NOSi
Molecular Weight:292.28
Hs Code.:
Mol file:221095-71-2.mol

Synonyms:4-((tert-butyldimethylsilyloxy)methyl)-2,6-dichloropyridine

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Chemical Property of 4-((tert-butyldimethylsilyloxy)methyl)-2,6-dichloropyridine

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Technology Process of 4-((tert-butyldimethylsilyloxy)methyl)-2,6-dichloropyridine

There total 1 articles about 4-((tert-butyldimethylsilyloxy)methyl)-2,6-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 221095-71-2
2,6-dichloro-4-((1,1-dimethylethyl)dimethylsilyl)oxymethylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / BH₃*SMe₂ / tetrahydrofuran / 12 h / 80 °C

2: 91 percent / imidazole; 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 23 °C

With 1H-imidazole; dmap; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja043682p

Reference yield: 69.0%

: 138642-47-4
2-bromo-5-methoxybenzonitrile

: 221095-71-2
2,6-dichloro-4-((1,1-dimethylethyl)dimethylsilyl)oxymethylpyridine

: C₂₈H₃₁N₃O₃Si

Guidance literature:: 2-bromo-5-methoxybenzonitrile; With n-butyllithium; In tetrahydrofuran; hexane; at -100 ℃; for 0.0833333h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -100 - 23 ℃; Inert atmosphere;

2,6-dichloro-4-((1,1-dimethylethyl)dimethylsilyl)oxymethylpyridine; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; at 80 ℃; for 14h; Inert atmosphere;
DOI:10.1021/ol902902m

Reference yield:

: 1233968-22-3
C₈H₈BNO₃

: 221095-71-2
2,6-dichloro-4-((1,1-dimethylethyl)dimethylsilyl)oxymethylpyridine

: C₂₈H₃₁N₃O₃Si

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tri-tert-butyl phosphine; caesium carbonate; In tetrahydrofuran; at 80 ℃; for 12h;
DOI:10.1021/ja043682p