3-AMINO-5-METHYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE

Base Information

• Chemical Name: 3-AMINO-5-METHYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE
• CAS No.: 205989-36-2
• Molecular Formula: C10H11N3O
• Molecular Weight: 189.21
• Mol file: 205989-36-2.mol

Synonyms:3-AMINO-5-METHYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE;3-amino-5-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one

Chemical Property of 3-AMINO-5-METHYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE

Chemical Property:

• Vapor Pressure: 4.73E-06mmHg at 25°C
• Boiling Point: 382.4°C at 760 mmHg
• Flash Point: 185.1°C
• PSA: 67.48000
• Density: 1.35g/cm³
• LogP: 1.00640

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-5-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-5-METHYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE

There total 2 articles about 3-AMINO-5-METHYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dihydro-5-methyl-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one (157837-04-2) → 3-amino-5-methyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one (205989-36-2)

Guidance literature:

With hydrogen bromide; acetic acid; at 70 ℃; for 0.5h;

DOI:10.1021/jm051185t

Reference yield:

[(2-acetyl-phenylcarbamoyl)-benzotriazol-1-yl-methyl]-carbamic acid benzyl ester (173459-40-0) → 3-amino-5-methyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one (205989-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NH₃ / methanol; tetrahydrofuran / 18 h

1.2: NH₄OAc; AcOH / 18 h / 20 °C

2.1: 857 mg / HBr; AcOH / 0.5 h / 70 °C

With ammonia; hydrogen bromide; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1021/jm051185t

Reference yield: 48.0%

3-amino-5-methyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one (205989-36-2) + 4-methoxy-benzoyl chloride (100-07-2) → 4-methoxy-N-(5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/jm051185t

upstream raw materials:

1,3-dihydro-5-methyl-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one

[(2-acetyl-phenylcarbamoyl)-benzotriazol-1-yl-methyl]-carbamic acid benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 205989-36-2 3-AMINO-5-METHYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE

Send

Send

Metric Ton KG G Pound L ML

Send

Send