1-(Oxetan-3-yl)-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Base Information

• Chemical Name: 1-(Oxetan-3-yl)-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea
• CAS No.: 1260088-68-3
• Molecular Formula: C16H23BN2O4
• Molecular Weight: 318.181
• Hs Code.: 2934999090
• Mol file: 1260088-68-3.mol

Synonyms:1-(Oxetan-3-yl)-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Chemical Property of 1-(Oxetan-3-yl)-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

Chemical Property:

• PSA: 68.82000
• LogP: 1.97000

Purity/Quality:

97% ^*data from raw suppliers

1-(Oxetan-3-yl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Oxetan-3-yl)-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

There total 1 articles about 1-(Oxetan-3-yl)-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

phosgene (75-44-5) + oxetan-3-amine hydrochloride (491588-41-1) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → 1-(oxetan-3-yl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (1260088-68-3)

Guidance literature:

phosgene; 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline; With pyridine; In dichloromethane; toluene; at 0 ℃; for 1h;

oxetan-3-amine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 20 ℃; for 12h;

Reference yield: 21.0%

(S)-2-chloro-7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidine (1260088-73-0) + 1-(oxetan-3-yl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (1260088-68-3) → (S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-(oxetan-3-yl)urea (1260088-74-1)

Guidance literature:

With potassium acetate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; at 110 ℃; for 0.5h; Microwave irradiation;

Reference yield:

1-(oxetan-3-yl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (1260088-68-3) + 2-(4-(benzyloxy)phenyl)-8-iodo-5,7-dimethoxy-4H-chromen-4-one → C26H22N2O7

Guidance literature:

1-(oxetan-3-yl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea; 2-(4-(benzyloxy)phenyl)-8-iodo-5,7-dimethoxy-4H-chromen-4-one; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In water; N,N-dimethyl-formamide; at 110 ℃;

With aluminum (III) chloride; at 85 ℃;

With boron tribromide; at 20 ℃;

DOI:10.1016/j.bcp.2021.114620

upstream raw materials:

phosgene

oxetan-3-amine hydrochloride

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

Downstream raw materials:

(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-(oxetan-3-yl)urea

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