2,2-Difluoro-4-iodobenzo[d][1,3]dioxole

Base Information

• Chemical Name: 2,2-Difluoro-4-iodobenzo[d][1,3]dioxole
• CAS No.: 531508-54-0
• Molecular Formula: C₇H₃F₂IO₂
• Molecular Weight: 284.001
• Hs Code.: 2932990090
• Mol file: 531508-54-0.mol

Synonyms:2,2-Difluoro-4-iodobenzo[d][1,3]dioxole;2,2-difluoro-4-iodo-2H-1,3-benzodioxole;2,2-Difluoro-4-iodo-1,3-benzodioxole

Chemical Property of 2,2-Difluoro-4-iodobenzo[d][1,3]dioxole

Chemical Property:

• PSA: 18.46000
• LogP: 2.61270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

4-Iodo-2,2-difluoro-1,3-benzodioxole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-Difluoro-4-iodobenzo[d][1,3]dioxole

There total 1 articles about 2,2-Difluoro-4-iodobenzo[d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,2-difluoro-1,3-benzodioxole (1583-59-1) → 2,2-difluoro-4-iodobenzo[d][1,3]dioxole (531508-54-0)

Guidance literature:

With iodine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -75 ℃; for 2h;

DOI:10.1002/ejoc.200390079

Reference yield:

2,2-difluoro-4-iodobenzo[d][1,3]dioxole (531508-54-0) → 3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate (531508-58-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / palladium(II)-acetate; triethylamine / acetonitrile / 4 h / 80 °C

2: 100 percent / formic acid / 2 h / 100 °C

3: 84 percent / lithium aluminum hydride / diethyl ether / 2 h / Heating

4: 81 percent / potassium hydroxide / diethyl ether; H₂O / 15 h / 25 °C

With potassium hydroxide; lithium aluminium tetrahydride; formic acid; palladium diacetate; triethylamine; In diethyl ether; water; acetonitrile;

DOI:10.1002/ejoc.200390079

upstream raw materials:

2,2-difluoro-1,3-benzodioxole

Downstream raw materials:

3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate

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