3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate

Base Information

• Chemical Name: 3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate
• CAS No.: 531508-58-4
• Molecular Formula: C₁₆H₁₄F₂O₅S
• Molecular Weight: 356.347
• Mol file: 531508-58-4.mol

Synonyms:

Chemical Property of 3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate

There total 7 articles about 3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-difluoro-4-iodobenzo[d][1,3]dioxole (531508-54-0) → 3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate (531508-58-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / palladium(II)-acetate; triethylamine / acetonitrile / 4 h / 80 °C

2: 100 percent / formic acid / 2 h / 100 °C

3: 84 percent / lithium aluminum hydride / diethyl ether / 2 h / Heating

4: 81 percent / potassium hydroxide / diethyl ether; H₂O / 15 h / 25 °C

With potassium hydroxide; lithium aluminium tetrahydride; formic acid; palladium diacetate; triethylamine; In diethyl ether; water; acetonitrile;

DOI:10.1002/ejoc.200390079

Reference yield:

tert-butyl (E)-3-(2,2-difluoro-1,3-benzodioxol-4-yl)-1-propenate (531508-42-6) → 3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate (531508-58-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / formic acid / 2 h / 100 °C

2: 84 percent / lithium aluminum hydride / diethyl ether / 2 h / Heating

3: 81 percent / potassium hydroxide / diethyl ether; H₂O / 15 h / 25 °C

With potassium hydroxide; lithium aluminium tetrahydride; formic acid; In diethyl ether; water;

DOI:10.1002/ejoc.200390079

Reference yield:

2,2-difluoro-1,3-benzodioxol-4-yl-carbaldehyde (119895-68-0) → 3-(2,2-difluoro-1,3-benzodioxol-4-yl)propyl benzenesulfonate (531508-58-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / sodium acetate / 4 h / 250 °C

2: 84 percent / lithium aluminum hydride / diethyl ether / 2 h / Heating

3: 81 percent / potassium hydroxide / diethyl ether; H₂O / 15 h / 25 °C

With potassium hydroxide; lithium aluminium tetrahydride; sodium acetate; In diethyl ether; water; 1: Perkin condensation;

DOI:10.1002/ejoc.200390079

upstream raw materials:

2,2-difluoro-1,3-benzodioxol-4-yl-carbaldehyde

2,2-difluoro-4-methyl-1,3-benzodioxole

4-bromo-2,2-difluoro-1,3-benzodioxole

2,2-difluoro-4-iodobenzo[d][1,3]dioxole