3-(4-(2-aMinoethylaMino)-1,2,5-oxadiazol-3-yl)-4-(3-broMo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

Base Information

Chemical Name:3-(4-(2-aMinoethylaMino)-1,2,5-oxadiazol-3-yl)-4-(3-broMo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide
CAS No.:1204669-57-7
Molecular Formula:C12H11BrFIN6O3
Molecular Weight:513.065
Hs Code.:
Mol file:1204669-57-7.mol

Synonyms:3-(4-(2-aMinoethylaMino)-1,2,5-oxadiazol-3-yl)-4-(3-broMo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

Suppliers and Price of 3-(4-(2-aMinoethylaMino)-1,2,5-oxadiazol-3-yl)-4-(3-broMo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(4-(2-Aminoethylamino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-oneHydroiodide
1mg
$ 45.00

Alichem
3-(4-((2-Aminoethyl)amino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4h)-onehydroiodide
1g
$ 1345.83

Total 2 raw suppliers

Chemical Property of 3-(4-(2-aMinoethylaMino)-1,2,5-oxadiazol-3-yl)-4-(3-broMo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

Chemical Property:

PSA：125.00000
LogP:2.91920

Purity/Quality:

≥99% ^*data from raw suppliers

3-(4-(2-Aminoethylamino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-oneHydroiodide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-(4-(2-Aminoethylamino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one Hydroiodide is used as a reactant in the synthesis of indoleamine dioxygenase/histone deacetylase dual inhibitors.

Technology Process of 3-(4-(2-aMinoethylaMino)-1,2,5-oxadiazol-3-yl)-4-(3-broMo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

There total 8 articles about 3-(4-(2-aMinoethylaMino)-1,2,5-oxadiazol-3-yl)-4-(3-broMo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1204669-66-8
3-(4-((2-azidoethyl)amino)-1,2,5-oxadiazole-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazole-5(4H)-one

: 1204669-57-7
3-(4-((2-aminoethyl)amino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In methanol; at 20 ℃; for 4h;

Reference yield:

: 1204669-63-5
4-(3-bromo-4-fluorophenyl)-3-{4-[(2-methoxyethyl)amino]-1,2,5-oxadiazol-3-yl}-1,2,4-oxadiazol-5(4H)-one

: 1204669-57-7
3-(4-((2-aminoethyl)amino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 1 h / 0 °C

1.2: 2.92 h / 20 °C

1.3: 6 h / 50 °C

2.1: sodium iodide; chloro-trimethyl-silane / methanol / 1 h / 20 - 42 °C

With chloro-trimethyl-silane; boron tribromide; sodium iodide; In methanol; dichloromethane;

Reference yield:

: 1204669-59-9
4-amino-N‘-hydroxy-N-(2-methoxyethyl)-1,2,5-oxadiazole-3-carboximidamide

: 1204669-57-7
3-(4-((2-aminoethyl)amino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydroiodide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / water / 15 h / 100 °C

2.1: sodium chloride; sodium nitrite; hydrogenchloride / water; ethyl acetate / 3 - 20 °C

3.1: water / 0.17 h / 60 °C

3.2: 0.58 h

4.1: ethyl acetate / 0.33 h / 60 °C

5.1: boron tribromide / dichloromethane / 1 h / 0 °C

5.2: 2.92 h / 20 °C

5.3: 6 h / 50 °C

6.1: sodium iodide; chloro-trimethyl-silane / methanol / 1 h / 20 - 42 °C

With hydrogenchloride; chloro-trimethyl-silane; sodium chloride; boron tribromide; sodium iodide; potassium hydroxide; sodium nitrite; In methanol; dichloromethane; water; ethyl acetate;