L-Proline, 4,4-difluoro-5-oxo-, methyl ester (9CI)

Base Information

Chemical Name:L-Proline, 4,4-difluoro-5-oxo-, methyl ester (9CI)
CAS No.:333956-61-9
Molecular Formula:C₆H₇F₂NO₃
Molecular Weight:179.123
Hs Code.:
Mol file:333956-61-9.mol

Synonyms:L-Proline, 4,4-difluoro-5-oxo-, methyl ester (9CI);L-Proline, 4,4-difluoro-5-oxo-, methyl ester;4,4-difluoro-5-oxo-L-Proline Methyl ester

Suppliers and Price of L-Proline, 4,4-difluoro-5-oxo-, methyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of L-Proline, 4,4-difluoro-5-oxo-, methyl ester (9CI)

Chemical Property:

PSA：55.40000
LogP:0.01200

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Proline, 4,4-difluoro-5-oxo-, methyl ester (9CI)

There total 3 articles about L-Proline, 4,4-difluoro-5-oxo-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (S)-1-tert-butyl 2-methyl 4,4-difluoro-5-oxopyrrolidine-1,2-dicarboxylate

: 333956-61-9
methyl (5S)-3,3-difluoro-2-oxopyrrolidine-5-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;
DOI:10.1021/acsmedchemlett.0c00496

Reference yield:

: 102195-80-2
(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

: 333956-61-9
methyl (5S)-3,3-difluoro-2-oxopyrrolidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 18.25 h / -78 - 20 °C

2: sodium periodate; ruthenium(III) trichloride hydrate / water; ethyl acetate / 17 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

With sodium periodate; diethylamino-sulfur trifluoride; ruthenium(III) trichloride hydrate; trifluoroacetic acid; In dichloromethane; water; ethyl acetate;
DOI:10.1021/acsmedchemlett.0c00496

Reference yield:

: 203866-17-5
1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

: 333956-61-9
methyl (5S)-3,3-difluoro-2-oxopyrrolidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate; ruthenium(III) trichloride hydrate / water; ethyl acetate / 17 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

With sodium periodate; ruthenium(III) trichloride hydrate; trifluoroacetic acid; In dichloromethane; water; ethyl acetate;
DOI:10.1021/acsmedchemlett.0c00496