(1r,2r,4s)-rel-7-boc-7-azabicyclo[2.2.1]heptan-2-ol

Base Information

• Chemical Name: (1r,2r,4s)-rel-7-boc-7-azabicyclo[2.2.1]heptan-2-ol
• CAS No.: 152533-46-5
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.277
• Mol file: 152533-46-5.mol

Synonyms:(1r,2r,4s)-rel-7-boc-7-azabicyclo[2.2.1]heptan-2-ol;(1R,2R,4S)-rel-tert-Butyl 2-hydroxy-7-azabicyclo[2.2.1]heptane-7-carboxylate

Chemical Property of (1r,2r,4s)-rel-7-boc-7-azabicyclo[2.2.1]heptan-2-ol

Chemical Property:

• Boiling Point: 310.3±25.0 °C(Predicted)
• PKA: 14.72±0.20(Predicted)
• PSA: 49.77000
• Density: 1.181±0.06 g/cm3(Predicted)
• LogP: 1.45700

Purity/Quality:

99%, ^*data from raw suppliers

(1R,2R,4S)-rel-7-Boc-7-azabicyclo[2.2.1]heptan-2-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1r,2r,4s)-rel-7-boc-7-azabicyclo[2.2.1]heptan-2-ol

There total 105 articles about (1r,2r,4s)-rel-7-boc-7-azabicyclo[2.2.1]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(1S,2R,4R)-2-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester (154905-37-0) → (+)-exo-7-<(1,1-Domethylethoxy)carbonyl>-7-azabicyclo<2.2.1>heptan-2-ol (154905-38-1,152533-46-5,154905-36-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Ambient temperature;

DOI:10.1021/jo00086a030

Reference yield: 85.0%

(1R,2S,4S)-2-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester (154905-40-5) → (-)-exo-7-<(1,1-Domethylethoxy)carbonyl>-7-azabicyclo<2.2.1>heptan-2-ol (154905-39-2,152533-46-5,154905-36-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Ambient temperature;

DOI:10.1021/jo00086a030

Reference yield: 82.0%

(exo)-7-(1,1-dimethylethoxycarbonyl)-7-azabicyclo[2.2.1]heptan-2-one (152533-47-6,163513-98-2) → (2-endo)-2-hydroxy-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester (152533-46-5,154905-36-9)

Guidance literature:

With L-Selectride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1021/jo00086a030

upstream raw materials:

di-tert-butyl dicarbonate

2-endo-hydroxy-7-azanorbornane

7-tert-butoxycarbonyl-7-azabicyclo<2.2.1>heptane

(3aR,7aS)-2,2-dimethyltetrahydrobenzo[d][1,3]dioxol-5(6H)-one

Downstream raw materials:

(exo)-7-(1,1-dimethylethoxycarbonyl)-7-azabicyclo[2.2.1]heptan-2-one

tert-butyl (1R,2R,4S)-2-hydroxy-7-azabicyclo[2.2.1]heptane-7-carboxylate

7-<(1,1-dimethylethoxy)carbonyl>-7-azabicyclo<2.2.1>heptan-2-endo-ol

(+)-epibatidine hydrochloride

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