154905-37-0

Basic information

• Product Name: (1S,2R,4R)-2-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester
• CAS NO: 154905-37-0
• Molecular Weight: 429.436
• Mol File: 154905-37-0.mol

Chemical Properties

• CAS DataBase Reference: (1S,2R,4R)-2-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R,4R)-2-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester(154905-37-0)
• EPA Substance Registry System: (1S,2R,4R)-2-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester(154905-37-0)

Safety Data

• Hazardous Substances Data: 154905-37-0(Hazardous Substances Data)

Upstream product

• 152533-42-1 N-Benzyl-N-cyclohex-3-enyl-2,2,2-trifluoro-acetamide 
• 78293-47-7 N-<(Trifluoroacetyl)amino>cyclohex-3-ene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 
• 152533-46-5 (±)-tert-butyl-(1SR,2RS,4RS)-2-hydroxy-7-azabicyclo[2.2.1]heptane-7-carboxylate 

Downstream Products

• 163513-99-3 (1S,4R)-7-(tert-Butoxycarbonyl)-7-azabicyclo<2.2.1>heptan-2-one 
• 152378-30-8 (-)-epibatidine 
• 154905-38-1 (+)-exo-7-<(1,1-Domethylethoxy)carbonyl>-7-azabicyclo<2.2.1>heptan-2-ol 

Relevant articles and documents

Total Synthesis and Determination of the Absolute Configuration of Epibatidine

The synthesis of (+)- and (-)-epibatidine (exo-2-(2-chloropyridin-5-yl)-7-azabicycloheptane) via reaction of 5-lithio-2-chloropyridine with (+)- and (-)-N-BOC-7-azabicycloheptan-2-one is described.The absolute configuration of the natural product is shown to be 1R,2R,4S.