5-Amino-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

• Chemical Name: 5-Amino-2,4-dihydro-[1,2,4]triazol-3-one
• CAS No.: 1003-35-6
• Molecular Formula: C2H4N4O
• Molecular Weight: 100.08
• Hs Code.: 2933990090
• Mol file: 1003-35-6.mol

Synonyms:s-Triazol-3-ol,5-amino- (6CI);D2-1,2,4-Triazolin-5-one,3-amino- (7CI,8CI);3-Amino-5-hydroxy-1,2,4-triazole;5-Amino-2,4-dihydro-3H-1,2,4-triazol-3-one;NSC 138436;

Chemical Property of 5-Amino-2,4-dihydro-[1,2,4]triazol-3-one

Chemical Property:

• Vapor Pressure: 1.26E-12mmHg at 25°C
• Melting Point: 286-290 °C (decomp)
• Refractive Index: 1.944
• Boiling Point: 548.1 °C at 760 mmHg
• PKA: 17.07±0.20(Predicted)
• Flash Point: 285.3 °C
• PSA: 87.56000
• Density: 2.27 g/cm³
• LogP: -0.73860
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Amino-4,5-dihydro-1H-1,2,4-triazol-5-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Amino-2,4-dihydro-[1,2,4]triazol-3-one

There total 10 articles about 5-Amino-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-nitro-1,2,4-triazol-5-one (932-64-9) → 5-amino-2,4-dihydro-3H-1,2,4-triazol-3-one (1003-35-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 5h; under 1551.44 Torr;

DOI:10.1002/(SICI)1099-1344(199912)42:12<1203::AID-JLCR276>3.0.CO;2-F

Reference yield: 39.0%

3-nitro-1,2,4-triazol-5-one (932-64-9) → C4H4N8O2 (1352233-46-5) + C4H4N8O3 (960607-22-1) + 5-amino-2,4-dihydro-3H-1,2,4-triazol-3-one (1003-35-6)

Guidance literature:

With sodium sulfate; In water; pH=2 - 7; Electrolysis;

DOI:10.1039/c1nj20770a

Reference yield:

C4H4N8O3 (960607-22-1) → 5-amino-2,4-dihydro-3H-1,2,4-triazol-3-one (1003-35-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; water; under 760.051 Torr;

DOI:10.1039/c1nj20770a

upstream raw materials:

1-aminoguanidine hydrochloride

urea

3-nitro-1,2,4-triazol-5-one

C₄H₄N₈O₃

Downstream raw materials:

3-hydroxy-6-phenyl-7-(2-hydroxy-3-bromo-4-isopropoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrimidine

3-hydroxy-6-phenyl-7-(2-hydroxy-4-methoxy-6-methylphenyl)-[1,2,4]triazolo[4,3-a]pyrimidine

3-hydroxy-6-phenyl-7-(2-hydroxy-4-isopropoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrimidine

3-hydroxy-6-(4-methoxyphenyl)-7-(2-hydroxy-4-benzyloxyphenyl)-[1,2,4]triazolo[4,3-a]pyrimidine

Refernces

• 1、 Wallace, Lynne,Underwood, Christie J.,Day, Anthony I.,Buck, Damian P.. "Electrochemical reduction of nitrotriazoles in aqueous media as an approach to the synthesis of new green energetic materials". experimental part. p. 2894 - 2901. Retrieved 2012/01/14.