(R)-1-(3,5-difluoropyridin-2-yl)-2-MethoxyethanaMine

Base Information

• Chemical Name: (R)-1-(3,5-difluoropyridin-2-yl)-2-MethoxyethanaMine
• CAS No.: 1075757-20-8
• Molecular Formula: C8H10F2N2O
• Molecular Weight: 188.1746064
• Hs Code.: 2933399090
• Mol file: 1075757-20-8.mol

Synonyms:(R)-1-(3,5-difluoropyridin-2-yl)-2-MethoxyethanaMine

Chemical Property of (R)-1-(3,5-difluoropyridin-2-yl)-2-MethoxyethanaMine

Chemical Property:

• Boiling Point: 208.7±35.0 °C(Predicted)
• PKA: 7.15±0.50(Predicted)
• PSA: 48.14000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 1.70630
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-1-(3,5-Difluoropyridin-2-yl)-2-methoxyethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(3,5-difluoropyridin-2-yl)-2-MethoxyethanaMine

There total 3 articles about (R)-1-(3,5-difluoropyridin-2-yl)-2-MethoxyethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (1075757-32-2,1075757-20-8) + (S)-Mandelic acid (17199-29-0) → 1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (1075757-20-8) + (R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (L)-mandelate (1075757-21-9)

Guidance literature:

In ethyl acetate; Resolution of racemate;

Reference yield:

1-(3,5-difluoropyridin-2-yl)-N-hydroxy-2-methoxyethanimine (1075757-31-1) → 1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (1075757-20-8) + (R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (L)-mandelate (1075757-21-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate / 1 h / 40 °C / 3750.38 Torr

2: ethyl acetate / Resolution of racemate

With hydrogen; palladium on activated charcoal; In ethyl acetate;

Reference yield:

1-(3,5-difluoropyridin-2-yl)-N-hydroxy-2-methoxyethanimine (1075757-31-1) → 1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (1075757-32-2,1075757-20-8)

Guidance literature:

With hydrogen; 1% Pd/C; In ethyl acetate; at 40 ℃; for 1h; under 3750.38 Torr;

upstream raw materials:

1-(3,5-difluoropyridin-2-yl)-N-hydroxy-2-methoxyethanimine

1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine

(S)-Mandelic acid

Downstream raw materials:

(1R)-1-(3,5-difluoropyridin-2-yl)-2-methoxyethanamine (R)-mandelic acid salt

Refernces

• 1、 -. "PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER". Page/Page column 109-110. . Retrieved 2008/12/08.