(4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester

Base Information

Chemical Name:(4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester
CAS No.:148809-28-3
Molecular Formula:C₁₃H₂₄O₅
Molecular Weight:260.331
Hs Code.:
Mol file:148809-28-3.mol

Synonyms:(4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester;2,4-Dideoxy-3,5-O-(1-Methylethylidene)-L-erythro-hexonic Acid 1,1-DiMethylethyl Ester

Suppliers and Price of (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(4S,6R)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-aceticAcid1,1-DimethylethylEster
100mg
$ 1350.00

Total 9 raw suppliers

Chemical Property of (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester

Chemical Property:

Boiling Point:330.9±17.0 °C(Predicted)
PKA:14.25±0.10(Predicted)
PSA：64.99000
Density:1.030±0.06 g/cm3(Predicted)
LogP:1.62070
Storage Temp.:Refrigerator
Solubility.:Chloroform, Ethyl Acetate, Methanol

Purity/Quality:

98%min ^*data from raw suppliers

(4S,6R)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-aceticAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester is a useful synthetic intermediate.

Technology Process of (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester

There total 3 articles about (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1044518-94-6
tert-butyl 2-((4S,6R)-6-[(tert-butyl)dimethylsilyloxymethyl]-2,2-dimethyl-1,3-dioxan-4-yl)acetate

: 148809-28-3,407577-54-2
[(4S,6R)-2,2-dimethyl-6-hydroxymethyl-1,3-dioxan-4-yl]acetic acid t-butyl ester

Guidance literature:: With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.200900231

Reference yield: 87.0%

: [(4S,6R)-6-benzoyloxymethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid t-butyl ester

: 148809-28-3,407577-54-2
[(4S,6R)-2,2-dimethyl-6-hydroxymethyl-1,3-dioxan-4-yl]acetic acid t-butyl ester

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 4h;
DOI:10.3762/bjoc.15.179

Reference yield:

: C₁₆H₂₀O₆

: 148809-28-3,407577-54-2
[(4S,6R)-2,2-dimethyl-6-hydroxymethyl-1,3-dioxan-4-yl]acetic acid t-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; di-tert-butyl dicarbonate / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique

2: methanol; potassium carbonate / 4 h / 20 °C

With methanol; dmap; di-tert-butyl dicarbonate; potassium carbonate;
DOI:10.3762/bjoc.15.179