(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

Base Information

Chemical Name:(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
CAS No.:1044518-75-3
Molecular Formula:C₁₃H₂₂O₅
Molecular Weight:258.315
Hs Code.:

Synonyms:(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

Suppliers and Price of (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,5-Dideoxy-2,4-O-(1-methylethylidene)-D-erythro-hexuronicAcid1,1-DimethylethylEster
50mg
$ 4950.00

Total 7 raw suppliers

Chemical Property of (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

Chemical Property:

Boiling Point:320.3±32.0 °C(Predicted)
Density:1.073±0.06 g/cm3(Predicted)

Purity/Quality:

> 95% ^*data from raw suppliers

3,5-Dideoxy-2,4-O-(1-methylethylidene)-D-erythro-hexuronicAcid1,1-DimethylethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3,5-Dideoxy-2,4-O-(1-methylethylidene)-D-erythro-hexuronic Acid 1,1-Dimethylethyl Ester is used in the synthesis of Amphotericin B.

Technology Process of (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

There total 2 articles about (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4R-cis)-6-chloro-2,2-dimethyl-1,3-dioxane-4-acetate tert-butyl ester

: 144-55-8
sodium hydrogencarbonate

: 1044518-75-3
(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

Guidance literature:: With potassium bromide; In dimethyl sulfoxide; at 140 ℃;

Reference yield:

: 148809-28-3,407577-54-2
[(4S,6R)-2,2-dimethyl-6-hydroxymethyl-1,3-dioxan-4-yl]acetic acid t-butyl ester

: 1044518-75-3
(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

Guidance literature:: With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; In dichloromethane; at 0 - 7 ℃; for 0.2h; pH=8.6; aq. buffer; Inert atmosphere;
DOI:10.1002/anie.200800589

Reference yield: 98.0%

: 1044518-75-3
(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

: 256659-02-6
(4R,6S)-4-(2-(benzyloxy)ethyl)-6-ethynyl-2,2-dimethyl-1,3-dioxane

: 1044518-76-4
tert-butyl 2-[(4S,6R)-6-((R)-3-((4S,6S)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-1-hydroxyprop-2-ynyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate

: tert-butyl 2-[(4S,6R)-6-((S)-3-((4S,6S)-6-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-1-hydroxyprop-2-ynyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Guidance literature:: (4R,6S)-4-(2-(benzyloxy)ethyl)-6-ethynyl-2,2-dimethyl-1,3-dioxane; With (-)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine; In toluene; at 20 ℃; for 3.5h; Inert atmosphere;

(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester; In toluene; at 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1002/anie.200800589