sp-420

Base Information

Chemical Name:sp-420
CAS No.:1221411-72-8
Molecular Formula:C18H25NO6S
Molecular Weight:383.466
Hs Code.:
Mol file:1221411-72-8.mol

Synonyms:(S)-4'-(HO)-DADFT-norPE-ethyl ester;(S)-4'-(HO)-DADFT-norPE-EE;ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl]-4-methyl-4-thiazolecarboxylate;

Suppliers and Price of sp-420

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of sp-420

Chemical Property:

Melting Point:68-70 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling Point:520.5±60.0 °C(Predicted)
PKA:8.78±0.40(Predicted)
PSA：111.88000
Density:1.24±0.1 g/cm3(Predicted)
LogP:1.68480

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of sp-420

There total 1 articles about sp-420 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 847829-15-6
ethyl (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

: 50586-80-6,58320-73-3
toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

: 1221411-72-8
ethyl (S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylate

Guidance literature:: With potassium carbonate; In acetone; for 48h; Reflux; Inert atmosphere;
DOI:10.1021/jm9018146

Reference yield: 80.0%

: 1221411-72-8
ethyl (S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylate

: 911714-45-9
(S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm9018146

Reference yield:

: 1221411-72-8
ethyl (S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylate

: 1221411-75-1
isopropyl (S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 6 h / 0 - 20 °C / Inert atmosphere

1.2: pH 2 / Cooling with ice; Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;