SP-420

Base Information

Chemical Name:SP-420
CAS No.:911714-45-9
Molecular Formula:C₁₆H₂₁NO₆S
Molecular Weight:355.412
Hs Code.:
Mol file:911714-45-9.mol

Synonyms:SP-420;(4S)-4,5-Dihydro-2-[2-hydroxy-4-[2-(2-methoxyethoxy)ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Suppliers and Price of SP-420

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
SP-420 >98%
1 g
$ 2400.00

DC Chemicals
SP-420 >98%
250 mg
$ 1200.00

DC Chemicals
SP-420 >98%
100 mg
$ 650.00

Crysdot
SP-420 98+%
25mg
$ 644.00

Crysdot
SP-420 98+%
5mg
$ 182.00

Crysdot
SP-420 98+%
10mg
$ 322.00

Chemenu
(S)-2-(2-hydroxy-4-(2-(2-methoxyethoxy)ethoxy)phenyl)-4-methyl-4,5-dihydrothiazole-4-carboxylicacid 98%
10mg
$ 301.00

Cayman Chemical
SP 420
25mg
$ 406.00

Cayman Chemical
SP 420
10mg
$ 190.00

Cayman Chemical
SP 420
5mg
$ 102.00

Total 10 raw suppliers

Chemical Property of SP-420

Chemical Property:

Melting Point:82-83℃ (ethyl acetate hexane )
Boiling Point:562.2±60.0 °C(Predicted)
PKA:1.02±0.40(Predicted)
PSA：122.88000
Density:1.32±0.1 g/cm3(Predicted)
LogP:1.20630

Purity/Quality:

99%, ^*data from raw suppliers

SP-420 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description SP 420 is an iron chelator and a derivative of desferrothiocin. It induces iron excretion in rat bile and urine with an iron-clearing efficiency (ICE) value of 26.7% when administered at a dose of 300 μmol/kg and decreases iron levels in rat liver and heart at 384 μmol/kg per day. SP 420 (75 μmol/kg) also induces iron excretion in iron-overloaded C. apella monkeys (ICE = 26.3%).

Technology Process of SP-420

There total 8 articles about SP-420 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1221411-72-8
ethyl (S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylate

: 911714-45-9
(S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm9018146

Reference yield:

: (S)-2-(chloroamino)-3-mercapto-2-methylpropanoic acid

: 1346427-93-7
trifluoromethanesulfonic 4-(2-(2-methoxyethoxy)ethoxy)-2-(trifluoromethylsulfonyloxy)benzimidic anhydride

: 911714-45-9
(S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: With triethylamine; In methanol; at 0 ℃; Reflux;

Reference yield:

: 50586-80-6,58320-73-3
toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

: 911714-45-9
(S)-4,5-dihydro-2-(2-hydroxy-4-(3,6-dioxaheptyloxy)phenyl)-4-methyl-4-thiazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 48 h / Reflux; Inert atmosphere

2.1: sodium hydroxide / methanol / 6 h / 0 - 20 °C / Inert atmosphere

2.2: pH 2 / Cooling with ice; Inert atmosphere

With potassium carbonate; sodium hydroxide; In methanol; acetone;