2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(hydroxymethyl)-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

Base Information

Chemical Name:2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(hydroxymethyl)-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-
CAS No.:171357-43-0
Molecular Formula:C21H19NO7
Molecular Weight:397.38
Hs Code.:
Mol file:171357-43-0.mol

Synonyms:2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(hydroxymethyl)-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

Suppliers and Price of 2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(hydroxymethyl)-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(hydroxymethyl)-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

Chemical Property:

Melting Point:169 - 171 °C
PSA：111.16000
LogP:1.86550

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(hydroxymethyl)-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)-

There total 1 articles about 2H-Cyclopentoxazol-2-one, 5,6-bis(benzoyloxy)hexahydro-4-(hydroxymethyl)-, 3aS-(3a.alpha.,4.alpha.,5.beta.,6.alpha.,6a.alpha.)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 165375-27-9
(1R,2R,3S,4S,5R)-4-(ethoxycarbonylamino)-3-hydroxy-5-(hydroxymethyl)cyclopentane-1,2-diyl dibenzoate

: 171357-43-0
(1S,5S)-7-endo-8-exo-dibenzoyloxy-6-exo-hydroxymethyl-2-oxa-4-azabicyclo[3.3.0]octan-3-one

Guidance literature:: With bis(tri-n-butyltin)oxide; In toluene; for 10h; Heating;
DOI:10.1016/S0008-6215(96)00172-3

Reference yield: 74.0%

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 171357-43-0
(1S,5S)-7-endo-8-exo-dibenzoyloxy-6-exo-hydroxymethyl-2-oxa-4-azabicyclo[3.3.0]octan-3-one

: 171357-44-1
(1S,5S)-7-endo-8-exo-dibenzoyloxy-6-exo-benzyloxymethyl-2-oxa-4-azabicyclo[3.3.0]octan-3-one

Guidance literature:: With trifluorormethanesulfonic acid; In 1,2-dichloro-ethane; for 4h; Ambient temperature;
DOI:10.1016/S0008-6215(96)00172-3

Reference yield:

: 171357-43-0
(1S,5S)-7-endo-8-exo-dibenzoyloxy-6-exo-hydroxymethyl-2-oxa-4-azabicyclo[3.3.0]octan-3-one

: C₅₆H₆₆N₄O₁₂

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / TfOH / 1,2-dichloro-ethane / 4 h / Ambient temperature

2: 1.) Me₃OBF₄, 4A molecular sieves / 1.) CH₂Cl₂, rt, 24 h, 2.) CH₂Cl₂, 24 h

3: 85 percent / methanol; triethylamine; H₂O / 72 h / Ambient temperature

4: 1.) TMSOTf, 4A molecular sieves, 2.) MeNH₂, H₂O / 1.) CH₂Cl₂, 0 deg C, 20 min; rt, 20 min, 2.) EtOH, rt, 48 h

With trifluorormethanesulfonic acid; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; water; trimethoxonium tetrafluoroborate; methylamine; In methanol; water; 1,2-dichloro-ethane; triethylamine;
DOI:10.1016/S0008-6215(96)00172-3